67839-04-7

Upstream product

• 86688-99-5 4-<1-(Phenylsulfonyl)-3-pyrrolyl>butyric acid 
• 591-50-4 iodobenzene 
• 23456-78-2 1,4,5,6-tetrahydro-7H-indol-7-one 

Downstream Products

• 1236887-89-0 6-[(dimethylamino)methylene]-1-phenyl-1,4,5,6-tetrahydro-7H-indol-7-one 
• 1314093-85-0 9-phenyl-6,9-dihydro-5H-pyrrolo[3,2-h]quinazoline 
• 1429642-06-7 C₁₅H₁₂N₂O 

Relevant academic research and scientific papers

PHOTOCHEMOTHERAPEUTIC HETEROCYCLIC AGENTS HAVING ANTIPROLIFERATIVE AND ANTINEOPLASTIC ACTIVITY

The present invention concerns the synthesis of new analogs of angelicins, pyrrolo [3,2-h]quinoline, for the treatment of pathologies having hyperproliferative character included those having neoplastic nature. The treatment is based on the combined actio

Synthesis of pyrrolo[3,2-h]quinolinones with good photochemotherapeutic activity and no DNA damage

In the search for new photochemotherapeutic agents, a series of derivatives of the ring system pyrrolo[3,2-h]quinoline - bioisosters of the angular furocoumarin angelicin - were synthesized through a four-step synthetic approach, in reasonable overall yields. Eight of the synthesized derivatives showed a remarkable phototoxicity against a panel of four human tumor cell lines and a great dose UV-A dependence, reaching IC50 values at submicromolar level. The mode of cellular death photoinduced by pyrrolo[3,2-h]quinolines was evaluated through a series of flow cytometric analysis and other tests were performed to clarify their mechanism of action.