67852-27-1

Usage

Biodegradable polymers

Commonly used in the preparation of biodegradable polymers, such as polylactic acid (PLA).

Applications

Widely used in biomedical applications, drug delivery systems, and packaging materials.

Spirocyclic structure

Gives the compound unique properties and makes it a valuable building block for the synthesis of various biocompatible materials.

Organic synthesis reagent

Used as a reagent in organic synthesis for the formation of diverse molecular architectures.

Upstream product

• 66461-70-9 α-hydroxycyclopentanecarboxamide 
• 105-58-8 Diethyl carbonate 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 5117-85-1 1-hydroxycyclopentanecarbonitrile 
• 23780-85-0 2'-Amino-cyclopentanspiro-5'-oxazolin-4'-on 
• 41248-23-1 hydroxycyclopentanecarboxylic acid ethyl ester 
• 3019-71-4 Trichloroacetyl isocyanate 
• 112101-08-3 2-Amino-3a-hydroxy-3a,4,5,6,7,7a-hexahydrobenzoxazol-7a-carbonsaeureamid 

Downstream Products

• 86344-79-8 3'-(N-benzyl-N-phenylaminomethyl)cyclopentanespiro-5'-oxazolidine-2',4'-dione 
• 86344-76-5 3'-<(4-benzhydrylpiperazino)methyl>cyclopentanespiro-5'-oxazolidine-2',4'-dione 
• 16841-19-3 1-hydroxy-cyclopentanecarboxylic acid 

Relevant academic research and scientific papers

A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from α-hydroxyesters using trichloroacetyl isocyanate

A convenient, high yield one-pot methodology for the synthesis of pharmaceutically interesting 3-unsubstituted-2,4-oxazolidinediones from α-hydroxyesters is described. A primary carbamate was generated in situ from the corresponding α-hydroxyester and tri

Study of the reaction between cyanohydrins and chlorosulfonyl isocyanate. A new, efficient method for the one-pot synthesis of 2,4-oxazolidinediones

The reaction between cyanohydrins and chlorosulfonyl isocyanate, followed by acid hydrolysis, provides and efficient route for the one-pot preparation of 5,5-disubstituted 2,4-oxazolidinediones.

A Ring Contraction Induced by Hydrogenperoxide

2-Amino-7a-carbamoyl-3a-hydroxy-3a,4,5,6,7,7a-hexahydro-benzoxazole (1) and hydrogenperoxide rearrange to 2'-amino-cyclopentanespiro-5'-oxazolin-4'-one (5). 5 and aniline hydrochloride form the phenylaminoderivative 6, 5 and 2,5-dichlorophenylhydrazine hydrochloride form the 2,5-dichlorophenylhydrazinederivative 7. 5 and hydrochloric acid afford cyclopentanespiro-5'-oxazolidin-2',4'-dione (8).Hydrolysis of 5 or 8 furnish 1-hydroxy-cyclopentane-carboxylic acid (9).