23780-85-0Relevant academic research and scientific papers
Oxazolones as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Sutin, Lori,Andersson, Soeren,Bergquist, Lars,Castro, Victor M.,Danielsson, Eva,James, Stephen,Henriksson, Martin,Johansson, Lars,Kaiser, Christina,Flyren, Katarina,Williams, Meredith
, p. 4837 - 4840 (2008/02/11)
2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.
A Ring Contraction Induced by Hydrogenperoxide
Bischoff, Christian,Gruendemann, Egon,Schroeder, Edith
, p. 184 - 186 (2007/10/02)
2-Amino-7a-carbamoyl-3a-hydroxy-3a,4,5,6,7,7a-hexahydro-benzoxazole (1) and hydrogenperoxide rearrange to 2'-amino-cyclopentanespiro-5'-oxazolin-4'-one (5). 5 and aniline hydrochloride form the phenylaminoderivative 6, 5 and 2,5-dichlorophenylhydrazine hydrochloride form the 2,5-dichlorophenylhydrazinederivative 7. 5 and hydrochloric acid afford cyclopentanespiro-5'-oxazolidin-2',4'-dione (8).Hydrolysis of 5 or 8 furnish 1-hydroxy-cyclopentane-carboxylic acid (9).
2-Amino-5-spiro substituted oxazoline-4-one compounds
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, (2008/06/13)
A novel series of 2-amino-5-spiro substituted oxazolin-4-ones and intermediates for making said compounds. These compounds are prepared by first converting the appropriately substituted cycloketone to the corresponding cyclocyanohydrin; converting this co
