67867-35-0

Usage

Uses

Used in Organic Synthesis:
(E)-2-(4-methoxyphenyl)-2-oxoacetaldehyde oxime is used as a building block for the synthesis of various pharmaceuticals and biologically active molecules. Its unique structure and oxime functional group contribute to its versatility in creating a wide array of compounds with potential applications in the medical field.
Used in Medicinal Chemistry:
In the realm of medicinal chemistry, (E)-2-(4-methoxyphenyl)-2-oxoacetaldehyde oxime is utilized as a key intermediate in the development of new drugs. Its ability to form oxime ethers, hydrazones, and other nitrogen-containing compounds makes it a valuable asset in the synthesis of complex organic molecules with therapeutic potential.
Used in the Synthesis of Heterocycles:
(E)-2-(4-methoxyphenyl)-2-oxoacetaldehyde oxime is also employed as a reagent in the synthesis of heterocycles, which are important components in many pharmaceuticals and natural products. Its involvement in this process aids in the creation of novel compounds with potential therapeutic properties.
Used in the Development of New Drugs:
(E)-2-(4-methoxyphenyl)-2-oxoacetaldehyde oxime plays a crucial role in the development of new drugs and compounds for various biological and therapeutic purposes. Its unique properties and reactivity make it an essential component in the design and synthesis of innovative pharmaceuticals aimed at treating a wide range of diseases and conditions.

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 540-80-7 tert.-butylnitrite 

Downstream Products

• 1287753-52-9 (E)-2-(4-methoxyphenyl)-2-oxoacetaldehyde O-benzyl oxime 
• 32345-64-5 1-(4-methoxyphenyl) ethane-1,2-diol 
• 46084-19-9 (S)-(+)-2-amino-1-(4-methoxyphenyl)-1-ethanol 
• 46084-23-5 (R)-(-)-2-Amino-1-(4-methoxyphenyl)-1-ethanol 
• 1287753-51-8 (E)-2-(4-methoxyphenyl)-2-oxoacetaldehyde O-methyl oxime 
• 3883-94-1 2-amino-4'-methoxyacetophenone hydrochloride 
• 848566-45-0 C₂₅H₁₉N₇O₂ 
• 135943-44-1 5,5''-di(4-methoxyphenyl)-2,2':6',2''-terpyridine 
• 850089-97-3 6-(4''-methoxyphenyl)-3-(2'-pyridyl)-1,2,4-triazine 

Relevant academic research and scientific papers

Single-Step Modular Synthesis of Unsaturated Morpholine N-Oxides and Their Cycloaddition Reactions

A single-flask procedure for the generation of α-keto-N-alkenylnitrones through a Chan–Lam coupling and subsequent spontaneous 6π electrocyclization of these intermediates for the synthesis of 2H-1,4-oxazine N-oxides has been developed for a variety of α-ketooximes and alkenylboronic acids. This transformation provides a new approach to C-substituted unsaturated morpholine derivatives that are poised to undergo further functionalization for the preparation of a diverse array of novel heterocyclic structures. The scope of the new method for the synthesis of 2H-1,4-oxazine N-oxides is discussed, in addition to initial studies describing the cycloaddition reactivity of these new heterocyclic intermediates.

Asymmetric reduction of α-keto aldoxime o -ethers

The catalytic asymmetric reduction of -keto aldoxime O-methyl, O-benzyl, and O-trityl ethers, derived from substituted acetophenones, with borane/oxazaborolidines, by transfer hydrogenation, and with yeast, was studied. The reduction with borane/oxazaborolidines produced the corresponding -hydroxy oxime ethers, -hydroxy hydroxylamine ethers, and -amino alcohols in 39-78% yields and up to 77% ee. The carbonyl group was selectively reduced by transfer hydrogenation with formic acid-triethylamine catalyzed by RhCl[(R,R)-TsDPEN](Ce, and also with yeast, producing -hydroxy oxime ethers, up to 75% ee and 93% ee, respectively. Georg Thieme Verlag Stuttgart New York.

THROMBOPOETIN RECEPTOR ACTIVATOR AND PROCESS FOR PRODUCING THE SAME

A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective or a platelet increasing agent, which contains a thrombopoietin receptor activator represented by the formula (1): [wherein each

An efficient route to 5-(hetero)aryl-2,4′- and 2,2′-bipyridines through readily available 3-pyridyl-1,2,4-triazines

A new route to substituted bipyridines based on a new method for the synthesis of substituted 3-pyridyl-1,2,4-triazines and their aza-Diels-Alder reactions is shown to be an efficient strategy for the preparation of structurally diverse bipyridine ligands.

An efficient route to 5,5″-diaryl-2,2′:6′,2″- terpyridines through 2,6-bis(1,2,4-triazin-3-yl)pyridines

A new route to substituted 2,2′:6′,2″-terpyridines based on a new method for the synthesis of substituted 2,6-bis(1,2,4-triazin-3-yl) pyridines and their inverse electron demand Diels-Alder reaction is shown to be an efficient strategy for the synthesis of structurally diverse terpyridine ligands.