850089-97-3

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 517876-04-9 6-(4-methoxy-phenyl)-3-pyridin-2-yl-3H-[1,2,4]triazin-4-ol 
• 1076-95-5 p-methoxyphenylglyoxal 
• 41939-98-4 C₉H₁₁N₃O₂ 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 67867-35-0 (E)-2-(4-methoxyphenyl)-2-oxoacetaldehyde oxime 

Downstream Products

• 173960-47-9 5-(4''-methoxyphenyl)-2,2'-bipyridine 
• 1204187-22-3 (R,S)-[6-(methoxyphenyl)-3-(2-pyridyl)-2,5-dihydro-2(H)-1,2,4-triazin-5-yl]ferrocene 
• 1415648-17-7 2-[6-(4-methoxyphenyl)-3-(2-pyridyl)-1,2,4-triazin-5-yl]-3-phenyl-1,4-diazaspiro[4.5]decane-1,3-diene 

Relevant academic research and scientific papers

Novel pentafluorophenyl- And alkoxyphenyl-appended 2,2'-bipyridine push-pull fluorophores: A convenient synthesis and photophysical studies

A convenient method for the synthesis of new highly in non-polar solvents soluble photoactive pentafluorophenyl-substituted and extended alkoxyphenyl-substituted 2,2'-bipyridines is reported. The synthetic strategy for the preparation of such ligands involves a sequence of several structural transformations, such as O-alkylation, nucleophilic substitution of hydrogen (S NH) in 1,2,4-triazine precursors via the 'addition-elimination' scheme, and the subsequent conversion of the obtained 1,2,4-triazines into 2,2'-bipyridines by means of the aza-Diels-Alder reaction. The photophysical properties of the synthesized novel pentafluoroaryl-substituted 2,2'-bipyridines were comprehensively studied. The obtained photophysical data indicate the competitive advantages of the herein reported pentafluoroarylated push-pull fluorophores, bearing extended aliphatic moieties, over their analogues containing benzoxy or phenolic fragments in terms of improvement in quantum yield and well-pronounced positive solvatochromism confirmed by the mathematical analysis according to the Lippert-Mataga equation.

The discovery of pyridinium 1,2,4-triazines with enhanced performance in bioconjugation reactions

1,2,4-Triazines have recently been identified as versatile dienes participating in the inverse electron-demand Diels-Alder reaction with strained dienophiles. However, their widespread utility in bioconjugation reactions is still limited. Herein, we repor

Facile synthesis of 6-aryl-3-pyridyl-1,2,4-triazines as a key step toward highly fluorescent 5-substituted bipyridines and their Zn(II) and Ru(II) complexes

A wide series of substituted bipyridines were obtained through the synthesis of 1,2,4-triazines and their aza Diels-Alder reactions. The reported method facilitates the synthesis of functionally diverse bipyridines that provides fine-tuning of photophysical properties of new ligands and their Zn(II) and Ru(II) complexes. Some of substituted bipyridines exhibit 'off-on' fluorescence response toward Zn2+ cations.

An efficient route to 5-(hetero)aryl-2,4′- and 2,2′-bipyridines through readily available 3-pyridyl-1,2,4-triazines

A new route to substituted bipyridines based on a new method for the synthesis of substituted 3-pyridyl-1,2,4-triazines and their aza-Diels-Alder reactions is shown to be an efficient strategy for the preparation of structurally diverse bipyridine ligands.