67868-44-4Relevant academic research and scientific papers
An efficient one-pot synthesis of 3,5-disubstituted 1H-pyrazoles
Wu, Lei-Lei,Ge, Yi-Cen,He, Ting,Zhang, Lei,Fu, Xing-Li,Fu, Hai-Yan,Chen, Hua,Li, Rui-Xiang
, p. 1577 - 1583 (2012/06/29)
An efficient, general, one-pot, three-component procedure for the preparation of 3,5-disubstituted 1H-pyrazoles via condensation of substituted aromatic aldehydes, tosylhydrazine and terminal alkynes in toluene is reported. The reaction tolerates a variety of functional groups and sterically hindered substrates to afford the desired pyrazoles in yields of 67-91%.
SYNTHESIS OF β-HYDROXYALKYLPYRAZOLES BY REACTION OF β-ARYLACRYLOYLOXIRANES WITH HYDRAZINE
Zvonok, A. M.,Kuz'menok, N. M.,Stanishevskii, L. S.
, p. 534 - 537 (2007/10/02)
Reaction of β-arylacryloyloxiranes with hydrazine hydrate takes place via intermediate α,β-epoxyalkylpyrazoles which then undergo intramolecular oxidative-reductive disproportionation to yield β-hydroxyalkylpyrazoles.
