67870-16-0

Usage

Uses

Used in Organic Synthesis:
Sodium pyridine-2-acetate is used as a reagent for its ability to catalyze reactions, facilitating the production of various organic compounds.
Used in Pharmaceutical Research and Drug Production:
Sodium pyridine-2-acetate is utilized as an intermediate in the synthesis of other organic compounds, playing a crucial role in the development and manufacturing of various drugs and pharmaceuticals.
It is important to handle sodium pyridine-2-acetate with care and follow proper safety protocols when working with it due to its reactivity and potential hazards.

InChI:InChI=1/C7H7NO2.Na/c9-7(10)5-6-3-1-2-4-8-6;/h1-4H,5H2,(H,9,10);/q;+1/p-1

Upstream product

• 16179-97-8 pyridin-2-yl acetic acid hydrochloride 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 

Downstream Products

• 1157-93-3 7-acetoxy-3-(2-pyridinyl)-2H-1-benzopyran-2-one 
• 1388891-26-6 N-methyl-2-(pyridin-2-yl)-N-[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]acetamide 

Relevant academic research and scientific papers

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK

Bruton's tyrosine kinase (BTK) has been shown to play a key role in the pathogenesis of autoimmunity. Therefore, the inhibition of the kinase activity of BTK with a small molecule inhibitor could offer a breakthrough in the clinical treatment of many autoimmune diseases. This Letter describes the discovery of BMS-986143 through systematic structure-activity relationship (SAR) development. This compound benefits from defined chirality derived from two rotationally stable atropisomeric axes, providing a potent and selective single atropisomer with desirable efficacy and tolerability profiles.

Insertion into the nickel-carbon bond of N-O chelated arylnickel(II) complexes. The development of single component catalysts for the oligomerisation of ethylene

A series of arylnickel phosphine complexes containing chelating N-O ligands, of the type [NiAr(N-O)L] [N-O = pyridine carboxylate (pyca); Ar = o-tolyl; L = PPh3, P(CH2Ph)3, PMePh2, PMe2Ph, PCy3: R = p-tolyl; L = PPh3: Ar = phenyl; L = PPh3 R = mesityl; L = PMePh2: N-O = pyridine acetate (pyac); Ar = mesityl; L = PMePh2] have been prepared, providing complexes with chelate ring sizes of five and six. Crystal structures for the complexes indicate that both complexes have square planar coordination about the nickel centre, with the nitrogen of the pyridine being trans to the phosphine in each case. Whereas significant bending and buckling of the six-membered chelate ring is evident for [Ni(mesityl)(pyac)PMePh2], the five-membered ring of [Ni(mesityl)(pyca)PMePh2] is essentially planar. On warming the complexes readily insert ethylene into the Ni-aryl bond, forming single component catalysts for the conversion of ethylene into higher oligomers with low to moderate activity. Products are linear with generally 60-80% having the double bond in the α-position. Catalyst activities and product distributions are markedly dependent on the phosphine present. Addition of excess PPh3 to the catalyst [Ni(o-tolyl)(pyca)PPh3] leads to a marked change in the product distribution with a less dramatic change in catalyst activity. A possible mechanism in which ethylene insertion occurs via an associative pathway from a five coordinate intermediate, [NiAr(CH2=CH2)(pyca)PR3], is suggested.