67879-06-5

Upstream product

• 108-30-5 succinic acid anhydride 
• 124-09-4 1,6-Hexanediamine 
• 105219-80-5 N-{6-[3-(4-Nitro-phenoxycarbonyl)-propionylamino]-hexyl}-succinamic acid 4-nitro-phenyl ester 

Relevant academic research and scientific papers

Preparation, characterization and copolymerization of the 12-membered cyclic diamide 1,6-diazacyclododecane-2,5-dione

A 12-membered cyclic diamide monomer for nylon 64 was successfully synthesized in fairly high yield (～45%). The synthesis conditions were varied to see the effect of the diamine and succinyl chloride reactants on yield. Threefold excess of 1,6-hexamethylenediamine (HDA) gave the highest yield, while further increasing the amount of HDA decreased the yield. Using N,N-diisopropylethylamine as acid scavenger resulted in the formation of two different cyclic amides, which were fully analyzed by 1H and 13C solution nuclear magnetic resonance spectrometry and mass spectrometry. Copolymerization of cyclic amides with ε-caprolactam via an anionic route gave a block copolyamide with a two distinct endotherms in the differential scanning calorimetry analysis. However, copolymerization by the hydrolytic route gave only nylon 6 with terminal 64 units.

COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS

The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups;of a monocarboxylic acid containing 6 to 32 carbon atoms;of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and(b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT

The present application relates to a cosmetic or pharmaceutical composition comprising a polycondensate capable of being obtained by the reaction of the following monomers alone: of 10 to 30% by weight, relative to the total weight of the polycondensate, of one or more polyols comprising 3 to 6 hydroxyl groups; of 30 to 80% by weight, relative to the total weight of the polycondensate, of one or more linear, branched and/or cyclic, saturated or unsaturated, non-aromatic monocarboxylic acids comprising 6 to 32 carbon atoms; of 1 to 40% by weight, relative to the total weight of the polycondensate, of one or more polycarboxylic acids and/or cyclic anhydrides of such a polycarboxylic acid and/or lactones comprising at least one COOH group; and optionally of 0.1 to 15% by weight, relative to the total weight of the polycondensate, of one or more silicones having a hydroxyl and/or carboxyl functional group. The application also relates to a method of cosmetic treatment using the said composition, and the polycondensate thus defined.

COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION

The present application relates to a cosmetic or pharmaceutical, in particular lipstick, composition comprising a polycondensate The application also relates to a method of cosmetic treatment using the composition, the polycondensate thus defined and a method of preparing the polycondensate.

Stability of activated phenyl esters of carboxylic acids in polar aprotic media

The reaction of activated phenyl esters of carboxylic acids with weakly basic aprotic solvents was investigated.It was established that only the most active 2,4-dinitrophenyl esters are subject to conversions with perceptible rate, principally hydrolysis.In weakly basic inert organic solvents triethylamine practically does not react with activated esters, while in HMPTA in accelerates hydrolysis by the mechanism of basic catalysis 3-36 times in dependence on the structure of the ester.Hydrolysis of 2,4-dinitrophenyl esters in the presence of triethylamine is accompanied by the formation of the intermediate anhydride as a result of acylation of the resulting carboxylic acid by the starting ester.It is shown that in aminolysis reactions an increase of the activity of the ester contributes to suppression of the competing reaction of hydrolysis.

IMMOBILIZATION OF ENZYMES INTRODUCING SPACERS. A SYNTHESIS OF CARRIERS WITH SPACERS OF VARIOUS LENGTH

A synthesis of spacers of various length and type, utilizing α,ω-dicarboxylic acids, α,ω-diaminoalkanes and succinic anhydride, condensation with carbodiimide, or introduction of -NCS functional groups is described.Carriers with a spacer were prepared by a method of binding the already synthesized spacer to the carrier (glass), and alternatively, by a stepwise synthesis of the spacer on the carrier surface.Carriers containing functional groups (37.2-39.3 μmol/g -NCS and 25-41.5 μmol/g -COOH) prepared in this way had total length of the spacer 0.62-3.92 nm.Whereas the length of the spacer is of no substantial importance for the reaction with low-molecular substances (L-valine, L-cysteine and 2-mercaptoethanol), the optimum length of the spacer for high-molecular compounds (albumin) is about 1.75-2.05 nm.The hydroxyl group adjacent to the functional group of the spacer (1,3-diaminopropan-2-ol) is also of noticeable influence.