67896-53-1

Usage

Uses

Used in Organic Synthesis:
[1-amino-3-(methylsulfanyl)propyl](hydroxy)oxophosphonium is used as a catalyst in the field of organic synthesis for its unique structure and reactivity, facilitating various chemical reactions and improving the efficiency of the synthesis process.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, [1-amino-3-(methylsulfanyl)propyl](hydroxy)oxophosphonium is used as a synthetic intermediate for the development of new drugs. The presence of the amino and hydroxy groups makes it a potential candidate for drug discovery and development, with further research and testing needed to explore its full potential.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical industry, [1-amino-3-(methylsulfanyl)propyl](hydroxy)oxophosphonium is utilized as a synthetic intermediate for the creation of new agrochemicals, such as pesticides and fertilizers, due to its unique reactivity and functional groups.
Used in Biochemical Research:
[1-amino-3-(methylsulfanyl)propyl](hydroxy)oxophosphonium also finds application in biochemical research, where it can be employed as a tool to study the interactions and mechanisms of various biological processes, potentially leading to new insights and discoveries in the field.

Upstream product

• 65577-34-6 (1-benzhydrylamino-3-methylsulfanyl-propyl)-phosphinic acid 
• 104165-04-0 1-amino-3-mercaptopropylphosphinic acid 
• 74-88-4 methyl iodide 
• 70569-52-7 3-methylthiopropanal oxime 

Downstream Products

• 234452-56-3 (+/-)-1-benzyloxycarbonylamino-3-methylthiopropylphosphonous acid 
• 30411-90-6 (RS)-<1-amino-3-(methylthio)propyl>phosphonic acid 

Relevant academic research and scientific papers

Synthesis of methionine- and norleucine-derived phosphinopeptides

We present herein a straightforward synthesis of N-Fmoc-protected synthons derived from a phosphinic analogue of methionine. These precursors were used successfully for the solid-phase synthesis of methionine-mimic phosphinopeptides using BOP-catalyzed coupling without protection of the phosphoryl moiety. We also prepared a new type of pseudopeptide derived from a phosphinic analogue of norleucine with a -PO(OH)-CH2-COOR moiety.

Stable organophosphorus analogues of S-adenosylmethionine and S-methylmethionine

The organophosphorus analogues of the biologically significant sulfonium compounds S-adenosylmethionine and S-methylmethionine are much more stable than their carboxylic prototypes.

Synthesis of phosphinic analogs of sulfur-containing amino acids

Phosphinic analogs of the key compounds of the metabolism of methionine were synthesized. The compounds obtained were selectively oxidized either at the phosphinic group or at the sulfur-containing fragment.

1-Aminoalkylphosphonous Acids. Part 1. Isosteres of the Protein Amino Acids

The synthesis of 1-aminoalkylphosphonous acids, isosteres of the protein amino acids, by addition of hypophosphorous acid to diphenylmethylimines is described.These analogues of glycine, alanine, valine, leucine, isoleucine, phenylalanine, tyrosine, tryptophan, serine, threonine, methionine, cysteine, cystine, glutamic acid, lysine, ornithine, arginine, and proline have been prepared and the analogues of alanine, valine, leucine, phenylalanine, and methionine resolved.The alanine, valine and methionine analogues have interesting antimicrobial activity and the alanine analogue has plant growth inhibiting properties.Oxidation of the appropriate 1-aminoalkylphosphonous acids gave the 1-aminoalkylphosphonic acid analogues of (+/-)-alanine, (-)-alanine, (+/-)-valine, (-)-valine, (+/-)-serine, (+/-)-threonine, (+/-)-lysine, (-)-leucine, and (+/-)-ornithine.