30411-90-6Relevant articles and documents
Conversion of nitriles to 1-aminophosphonic acids and preparation of phosphahomocysteines of high enantiomeric excess
Qian, Renzhe,Horak, Jeannie,Hammerschmidt, Friedrich
, p. 737 - 744 (2017/06/05)
A variety of nitriles was reduced to diisobutylaluminum salts of aldimines, to which diisopropyl phosphite was added. The corresponding 1-aminophosphonates were either deprotected to give racemic 1-aminophosphonic acids or reacted with Boc2O to yield N-Boc-protected 1-aminophosphonates. The enantiomers of 2-benzylthio-1-(t-butoxycarbonylamino)propylphosphonate were obtained from the racemate by chiral HPLC and converted to phosphonic acid analogs of (R)- and (S)-homocysteine, (R)- and (S)-2-aminobutyric acid and (S)-methionine, all of ee >97% as determined by chiral HPLC.
Enantioselective synthesis of diverse α-amino phosphonate diesters
Smith III, Amos B.,Yager, Kraig M.,Taylor, Carol M.
, p. 10879 - 10888 (2007/10/03)
An efficient, versatile protocol for the synthesis of highly enantioenriched α-amino phosphonate diesters has been devised. Addition of lithium diethyl phosphite to chiral chelating imines 31a-j, prepared from a variety of aldehydes and the chiral auxilia
Phosphohomocysteine Derivatives
Kudzin, Zbigniew H.,Stec, Wojciech J.
, p. 1032 - 1034 (2007/10/02)
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