678967-04-9Relevant articles and documents
Ceric Ammonium Sulfate (CAS) Mediated Oxidations of Benzophenones Possessing a Phenolic Substituent for the Synthesis of Xanthones and Related Products
Dam, Jean,Bode, Moira L.,De Koning, Charles B.
, p. 150 - 160 (2019/01/10)
Work previously published by our group described novel methodology for the synthesis of xanthones and related products from phenolic benzophenones in a reaction mediated by ceric ammonium sulfate (CAS). In this paper we further explore this novel reaction by subjecting an additional set of phenolic benzophenones to CAS to afford a range of compounds, including xanthones, 9H-xanthen-2,9(4aH)-diones, 3H-spiro[benzofuran-2,1′-cyclohexa[2,5]diene]-3,4′-diones, and biaryl compounds. A comparison of these reactions with the more commonly used oxidant ceric ammonium nitrate (CAN) was also conducted. Based on these results, greater insight into the reaction mechanism has been gained. In addition, the conversion of the synthesized xanthen-2,9(4aH)-diones to xanthones by treatment with sodium dithionite is described.
Selective syntheses of partially etherified derivatives of tetrakis(2-hydroxyphenyl)ethene. An alternative to the calix[4]arene ligand system
Fujita, Megumi,Qi, Guizhong,Verkerk, Udo H.,Dzwiniel, Trevor L.,McDonald, Robert,Stryker, Jeffrey M.
, p. 2653 - 2656 (2007/10/03)
Stereoselective syntheses of (E)- and (Z)-1,2-bis(2′-hydroxyphenyl)- bis(2′-methoxyphenyl)ethene have been developed, the former by convergent coupling of an orthogonally protected 2,2′-benzophenone derivative and the latter by selective partial dealkylat
Substituted tetraarylethylene compounds
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, (2008/06/13)
The present invention seeks to provide novel tetraarylethylene compounds which are substituted on the aryl rings ortho to the ethylenic carbon atoms and processes for the preparation for such compounds. The compounds have potential use as molecular templates.
Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors
Tawada,Natsugari,Ishikawa,Sugiyama,Ikeda,Meguro
, p. 616 - 625 (2007/10/02)
Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.