678967-32-3Relevant articles and documents
Orally active amino functionalized antimalarial 1,2,4-trioxanes
Singh, Chandan,Malik, Heetika,Puri, Sunil K.
, p. 459 - 462 (2004)
Using readily available trioxanes 6a-b, a new series of amino functionalized 1,2,4-trioxanes 8a-e and 9a-e have been prepared and evaluated for antimalarial activity against multi-drug resistant Plasmodium yoelii in Swiss mice model. Several of these nove
Protection of the carbonyl group as 1,2,4-trioxane and its regeneration under basic conditions
Singh, Chandan,Malik, Heetika
, p. 5673 - 5676 (2007/10/03)
(Chemical Equation Presented) An experimental protocol demonstrating the protection of the carbonyl group as 1,2,4-trioxane, the stability of the protecting group under a variety of reaction conditions, and the regeneration of the carbonyl group with Triton B in THF at room temperature is presented. The method provides a useful alternative for the protection of carbonyl compounds having acid-sensitive moieties.