Orally active amino functionalized antimalarial 1,2,4-trioxanes

Article abstract of DOI:10.1016/j.bmcl.2003.10.051

Using readily available trioxanes 6a-b, a new series of amino functionalized 1,2,4-trioxanes 8a-e and 9a-e have been prepared and evaluated for antimalarial activity against multi-drug resistant Plasmodium yoelii in Swiss mice model. Several of these nove