678982-65-5

Upstream product

• 558464-31-6 (RS)-tert-butyl 4-[(4-chlororbenzenesulfonyl)-(2,5-difluorophenyl)methyl]-piperidine-1-carboxylate 

Downstream Products

• 678982-62-2 (RS)-4-[(4-chlrorbenzenesulfonyl)-(2,5-difluorophenyl)methyl]-1-trifluoromethanesulfonyl-piperidine 
• 558464-32-7 4-[[(4-Chlorophenyl)sulfonyl] (2,5-difluorophenyl)methyl]piperidine hydrochloride 

Relevant academic research and scientific papers

HETEROCYCLIC METHYL SULFONE DERIVATIVE

Provided is a compound capable of inhibiting production or secretion of β amyloid protein. A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents -S-,-SO- or -SO2-) an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

NOVEL SULPHONES FOR INHIBITION OF GAMMA SECRETASE

The invention provides compounds of formula (I) : which are inhibitors of γ-secretase and hence useful in the treatment or prevention of Alzheimer's disease.