558464-31-6Relevant articles and documents
HETEROCYCLIC METHYL SULFONE DERIVATIVE
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Page/Page column 52, (2010/11/08)
Provided is a compound capable of inhibiting production or secretion of β amyloid protein. A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents -S-,-SO- or -SO2-) an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.
NOVEL SULPHONES FOR INHIBITION OF GAMMA SECRETASE
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Page 22-23, (2010/02/06)
The invention provides compounds of formula (I) : which are inhibitors of γ-secretase and hence useful in the treatment or prevention of Alzheimer's disease.