679002-59-6Relevant academic research and scientific papers
H-phosphonate mediated sulfonylation of 2-substituted quinoline N-oxides: One-pot strategy for the synthesis of 3/4-sulfonylquinoline derivatives
Ma, Huili,Liu, Shuyun,Zhu, Shaohua,Bi, Wenzhu,Chen, Xiaolan,Zhao, Yufen
, p. 887 - 895 (2017/08/15)
series of biologically important 3/4-sulfonylquinoline derivatives was synthesized starting from easily available sodium benzenesulfinates, diethyl H-phosphonate and 2-substituted quinoline N-oxides in onepot under metal-free conditions. H-phosphonate plays a decisive role in activating the C3-H, C4-H bonds of the 2-substituted quinoline N-oxides. The isolated 3/4-sulfonylquinolines were characterized by 1H, 13CNMR spectroscopy and HR MS.
Construction of Azacycles Based on Endo-Mode Cyclization of Allenes
Mukai, Chisato,Kobayashi, Minoru,Kubota, Shoko,Takahashi, Yukie,Kitagaki, Shinji
, p. 2128 - 2136 (2007/10/03)
A new procedure for constructing monocyclic five- and six-membered azacycles by the endo-mode ring-closing reaction of allenylazido derivatives under neutral conditions has been developed. The azabicyclo[m.n.0] compounds were prepared by applying this newly developed procedure. The seven-membered azacycle was prepared when the allene possessing an unsubstituted carboxyl amido functionality was submitted to the basic conditions. In addition, indole and quinoline skeletons were synthesized using this procedure.
