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11-DEHYDRO THROMBOXANE B2 is a metabolite of Thromboxane, a bioactive lipid mediator involved in platelet aggregation and vasoconstriction. It serves as an in vivo marker of oxidative stress and platelet activation, playing a significant role in the pathophysiology of various cardiovascular and inflammatory conditions.
Used in Pharmaceutical Industry:
11-DEHYDRO THROMBOXANE B2 is used as a biomarker for monitoring oxidative stress and platelet activation in patients with cardiovascular and inflammatory disorders. Its measurement can help in assessing the risk of adverse cardiovascular events and in guiding therapeutic interventions.
Used in Alzheimer's Disease Research:
In the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT), 11-DEHYDRO THROMBOXANE B2 is used as a biomarker to study its association with adverse cardiovascular events in Alzheimer's patients. This can provide insights into the role of oxidative stress and platelet activation in the progression of the disease and help in developing targeted therapies.

67910-12-7

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67910-12-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 67910-12-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,9,1 and 0 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 67910-12:
(7*6)+(6*7)+(5*9)+(4*1)+(3*0)+(2*1)+(1*2)=137
137 % 10 = 7
So 67910-12-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16+,17+,18-/m1/s1

67910-12-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 11-dehydro-thromboxane B2

1.2 Other means of identification

Product number -
Other names 11-Dehydro Thromboxane B2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:67910-12-7 SDS

67910-12-7Upstream product

67910-12-7Relevant academic research and scientific papers

Transformation of Prostaglandin D2 to 11-Dehydro Thromboxane B2 by Baeyer-Villiger Oxidation

Nakashima, Fumie,Schneider, Claus

, p. 73 - 78 (2020)

Prostaglandin D2 is one of five chief prostanoids formed in the cyclooxygenase pathway of arachidonic acid oxidation. Except for a single oxygen atom, PGD2 is structurally identical to 11-dehydro thromboxane B2 (11d-TxB2), a urinary metabolite of the pro-aggregatory platelet activator, thromboxane A2. The close structural relationship suggested that one might be transformed to the other. Accordingly, we tested whether the cyclopentanone of PGD2 can be expanded to the δ-lactone of 11d-TxB2 in a Baeyer-Villiger oxidation. Oxidation of PGD2 with two standard oxidants showed that 11d-TxB2 was formed only with H2O2 but not with peracetic acid. Byproducts of the H2O2-mediated oxidation were hydroperoxide derivatives and isomers of PGD2. Chemical oxidation of PGD2 to 11d-TxB2 may be a model for an equivalent enzymatic transformation, suggesting a possible link in the metabolism of PGD2 and thromboxane A2.

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