67915-01-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Hydroxyphenyl)-4-ethoxycarbonyl-piperazine is used as a therapeutic agent for the treatment of central nervous system disorders such as depression and anxiety. Its application is based on its ability to modulate neurotransmitter levels, particularly serotonin and dopamine, which are crucial for mood regulation.
Used in Neurodegenerative Disease Treatment:
In the field of neurodegenerative disease treatment, 1-(3-Hydroxyphenyl)-4-ethoxycarbonyl-piperazine is used as a potential therapeutic agent due to its antioxidant and anti-inflammatory properties. These characteristics make it a candidate for the treatment of conditions such as Alzheimer's disease, Parkinson's disease, and other related neurodegenerative disorders.

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 59817-32-2 3-(piperazin-1-yl)phenol 

Relevant academic research and scientific papers

NEM assisted real-time fluorescence detection of Cys in cytoplasm and mice imaging by a Coumarin probe containing carboxyl group

Alterations of the homeostasis balance of cysteine (Cys) are associated with a variety of diseases and cellular functions, and therefore, Cys dynamic real-time living cell intracellular imaging and quantification are important for understanding the pathophysiological processes. Thus, Cys probe that can permeate high efficiently is the first one to be affected. In fact, it is difficult for organic molecular probes to infiltrate cells because of the unique structure of the cell membrane. In this work, we found that probe containing-carboxyl just stagnated in cytomembrane due to carboxyl of probe and amino group of membrane protein forming peptide chains, nevertheless, the addition of NEM, improved membrane permeability by NEM reacting with sulfhydryl of membrane protein, which made probe permeate high efficiently and sequentially real-time detect the Cys in cytoplasm. It is the first time noted that NEM can regulate Cys probe containing-carboxyl for high efficient detection in cytoplasm. Additionally, probe was successfully applied to image Cys in mouse.

Carboxyl-containing coumarin derivative, as well as synthesizing method and application thereof

The invention discloses a carboxyl-containing coumarin derivative, as well as a synthesizing method and application thereof. The derivative has the name of (Z)-2-cyano-3-(4-((E)-3-(7-(4-(ethoxycarbonyl)piperazin-l-yl)-2-oxo-2H-chromen-3-yl)-3-oxoprop-l-en-l-yl)phenyl)acrylic acid, and is named as XI-2. The invention further provides a method for detecting specificity of cysteine with the derivative XI-2, which is used for quantitatively detecting the content of cysteine in a solution of PBS-DMSO(4:1,v/v, pH 7.4) through a fluorospectro photometer. The detection process is recyclable, simple, convenient, sensitive and quick, and the detection result is accurate. The invention further provides application of the derivative XI-2 in preparation of a cell cysteine detection reagent, which meansthat the XI-1 efficiently infiltrate cytomembrane to detect the cysteine in a cytoplasm under the NEM regulating effect.