59817-32-2

Basic information

• Product Name: 1-(3-HYDROXYPHENYL)PIPERAZINE
• Synonyms: RARECHEM AH CK 0118;N-(3-HYDROXYPHENYL)PIPERAZINE;3-(1-PIPERAZINO)PHENOL;1-(3-HYDROXYPHENYL)PIPERAZINE;Phenol, 3-(1-piperazinyl)- (9CI);1-(3-Hydroxyphenyl)piperazine 97%;3-PIPERAZIN-1-YLPHENOL;1-(3-HYDROXYPHENYL)-PIPERAZINE ( MHPP )
• CAS NO: 59817-32-2
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23
• EINECS: -0
• Product Categories: PIPERIDINE;Pyrazines;API intermediates;piperazines
• Mol File: 59817-32-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 217-221 °C(lit.)
• Boiling Point: 371.3oC at 760 mmHg
• Flash Point: 178.3oC
• Appearance: /
• Density: 1.141g/cm3
• Vapor Pressure: 4.89E-06mmHg at 25°C
• Refractive Index: 1.576
• PKA: 10.33±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 4248583
• CAS DataBase Reference: 1-(3-HYDROXYPHENYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-HYDROXYPHENYL)PIPERAZINE(59817-32-2)
• EPA Substance Registry System: 1-(3-HYDROXYPHENYL)PIPERAZINE(59817-32-2)

Safety Data

• Hazard Codes: Xn,C
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 59817-32-2(Hazardous Substances Data)

Usage

General Description

1-(3-Hydroxyphenyl)piperazine, also known as mCPP, is a chemical compound with a molecular formula C12H16N2O. It is a psychoactive drug belonging to the class of phenylpiperazine derivatives, and is commonly used in research to study the central nervous system and its effects on behavior. mCPP has been found to interact with various receptors in the brain, including serotonin, dopamine, and adrenergic receptors, leading to its potential role in mood regulation and behavior. It has also been investigated for its potential use in the treatment of mental health disorders such as anxiety and depression. However, the compound has also been linked to adverse effects including anxiety, agitation, and increased blood pressure, and its recreational use and misuse have led to regulatory control in various countries.

InChI:InChI=1/C10H14N2O/c13-10-3-1-2-9(8-10)12-6-4-11-5-7-12/h1-3,8,11,13H,4-7H2

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 591-27-5 m-Hydroxyaniline 
• 2398-37-0 3-methoxyphenyl bromide 
• 507263-18-5 tert-butyl 4-(3-methoxylphenyl)piperazine-1-carboxylate 
• 16015-71-7 4-(3-methoxyphenyl)piperazine 

Downstream Products

• 824409-50-9 acridin-9-yl-[4-(3-hydroxy-phenyl)-piperazin-1-yl]-methanone 
• 198627-86-0 1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate 
• 204122-18-9 1-benzyl-4-(3-hydroxyphenyl)piperazine 
• 346688-64-0 1-(3-hydroxyphenyl)-4-propylpiperazine 
• 1248587-58-7 3-(4-(1H-pyrrolo[2,3-b]pyridin-4-yl)piperazin-1-yl)phenol 
• 1444158-93-3 3-(4-phenylmethanesulfonylpiperazin-1-yl)phenol 
• 1577289-36-1 3-[4-(phenanthridin-6-yl)piperazin-1-yl]phenol 
• 1430328-48-5 C₁₄H₁₉F₃N₂O₃S 
• 346688-49-1 C₁₄H₂₂N₂O₃S 
• 1116383-53-9 benzyl 4-(3-hydroxyphenyl)piperazine-1-carboxylate 
• 1417454-13-7 C₂₀H₂₅FN₂O₂ 
• 1417454-23-9 C₂₈H₃₁FN₂O₄ 
• 1417454-12-6 C₂₄H₃₃N₃O₃ 
• 1426156-39-9 C₃₂H₃₉N₃O₅ 

Relevant articles and documents

Gasotransmitter Regulation of Phosphatase Activity in Live Cells Studied by Three-Channel Imaging Correlation

Enzyme activity in live cells is dynamically regulated by small-molecule transmitters for maintaining normal physiological functions. A few probes have been devised to measure intracellular enzyme activities by fluorescent imaging, but the study of the re

N-(2-acetyl-4-morpholinophenyl amide derivatives for inducing differentiation of mesenchymal stem cells to endothelial cells

The present invention refers to mesenchymal stem cells the vascular endothelial cells inducing their differentiation to the rarity piperidinyl/molpholine for containing amide derivatives and provides use thereof in medicaments. Said amide derivatives the middle ply treated with a vascular endothelial mesenchymal stem cells specifically cells differentiation induction, and are by using an balloon expansion alcoholic beverage like damage for vascular endothelial cells, such as by a vascular event for the effective treatment is enabled.

1-Substituted 4-(3-Hydroxyphenyl)piperazines are pure opioid receptor antagonists

This report describes the discovery that 1-substituted 4-(3-hydroxyphenyl) piperazines are pure opioid receptor antagonists. Compounds in this new series include N-phenylpropyl (3S)-3-methyl-4-(3-hydroxyphenyl)piperazine and (3R)-3-methyl-4-(3-hydroxyphenyl)piperazine, both of which display low nanomolar potencies at μ, δ, and κ receptors and pure antagonist properties in a [35S]GTPγS assay.