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Usage

Uses

Used in Pharmaceutical Industry:
(5Z)-5-(2-oxo-2-phenylethylidene)imidazolidine-2,4-dione is used as an anticonvulsant for its potential to help control seizures and prevent convulsions. Its ability to inhibit the release of neurotransmitters in the brain makes it a promising candidate for the development of new medications to treat epilepsy and other related conditions.
Used in Neurological Applications:
In the field of neurology, (5Z)-5-(2-oxo-2-phenylethylidene)imidazolidine-2,4-dione is used for its potential role in managing neurological disorders. Its neurotransmitter-inhibiting properties could be beneficial in the treatment of various conditions involving the overexcitation of neurons, such as anxiety, depression, and certain movement disorders.
Used in Cancer Treatment:
(5Z)-5-(2-oxo-2-phenylethylidene)imidazolidine-2,4-dione is used as a photosensitizer in photodynamic therapy for cancer treatment. Its ability to absorb light and generate reactive oxygen species can help in the destruction of cancerous cells, making it a valuable tool in the fight against various types of cancer.
Used in Chemical Research:
In the realm of chemical research, (5Z)-5-(2-oxo-2-phenylethylidene)imidazolidine-2,4-dione serves as a valuable compound for studying the properties and reactivity of imidazolidine-2,4-dione derivatives. Its unique structure and characteristics can provide insights into the development of new synthetic methods and applications for related heterocyclic compounds.

Upstream product

• 1074-12-0 phenylglyoxal hydrate 
• 95378-36-2 diethyl 2,4-dioxoimidazolidin-5-yl-phosphonate 
• 122351-53-5 2-Imino-4-oxo-5-[2-oxo-2-phenyl-eth-(E)-ylidene]-oxazolidine-3-carboxamidine 
• 127099-85-8 N-Cyanoguanidine 
• 55991-67-8 5-phenylfuran-2,3-dione 

Downstream Products

• 137920-74-2 5-(2-oxo-2-phenylethyl)-2,4-imidazolidinedione 

Relevant academic research and scientific papers

Diethyl 2,4-Dioxoimidazolidine-5-phosphonates: Horner-Wadsworth-Emmons Reagents for the Mild and Efficient Preparation of C-5 Unsaturated Hydantoin Derivatives

The phosphonates 19 and 20 were prepared from hydantoin and 1-methylhydantoin, respectively, by way of bromination at C-5 and a subsequent Michaelis-Arbuzov reaction with triethyl phosphite.The Horner-Wadsworth-Emmons-type reagents 19 and 20 were found to react readily with aromatic and aliphatic aldehydes, in the presence of a base, to produce C-5 unsaturated hydantoin derivatives 22 and 26, generally in high yield.The products 22 and 26 were frequently isolated as mixtures of E and Z isomers depending upon the identity of the aldehyde and phosphonate.The isomeric configuration of the products was determined from analysis of NMR spectral data.Long-range (13)C-(1)H coupling constants between the C-4 carbonyl of the hydantoin ring and the olefinic proton were found to be diagnostic of isomer geometry.Conditions were also developed that allowed coupling of 19 and 20 with cyclic and acyclic ketones and α-dicarbonyl compounds to afford the corresponding olefinic products.C-5 unsaturated hydantoin derivatives are of synthetic utility as precursors to α-amino acid derivatives, pyruvates, and the imidazoquinolin-2-one heterocyclic ring system, a class of potent inhibitors of low Km cAMP phosphodiesterase and the chromophore present in the siderophore azotobactin.

FIVE-MEMBERED 2,3-DIOXOHETEROCYCLES. 10. REACTION OF 5-ARYL-2,3-DIHYDROFURAN-2,3-DIONES WITH N-SUBSTITUTED UREAS AND THEIR THIO AND SELENO ANALOGS

3-Aryl-5-phenacylideneimidazolidine-2,4-diones, 3-aryl-5-phenacylidene-4-oxoimidazolidine-2-thiones, and 5-phenacylidene-4-oxoimidazolidine-2-selenones were obtained from 5-aryl-2,3-dihydrofuran-2,3-diones and arylureas, arylthioureas, and selenoureas res