67920-52-9

Basic information

• Product Name: Sodium danshensu
• Synonyms: 3-(3',4'-Dihydroxyphenyl)lactic acid sodium salt;Sodium DL-beta-(3,4-dihydroxyphenyl)lactate;Sodium danshensu;3,4-Dihydroxyphenyl-α-hydroxypropanoic acid sodium salt;3,4-Dihydroxyphenyl-.alpha.-hydroxypropanoic acid sodiuM salt;Sodium 3-(3,4-dihydroxyphenyl)lactate;DANSHENSU SODIUM (RG);Salvia natriuretic peptide
• CAS NO: 67920-52-9
• Molecular Formula: C₉H₉O₅*Na
• Molecular Weight: 220.155
• EINECS: 1592732-453-0
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
• Mol File: 67920-52-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Sodium danshensu(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium danshensu(67920-52-9)
• EPA Substance Registry System: Sodium danshensu(67920-52-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25
• Hazardous Substances Data: 67920-52-9(Hazardous Substances Data)

Usage

Description

Danshensu is a salvianolic acid and the major component of S. miltiorrhiza (Danshen) and has diverse biological activities. It reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage, and increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP) in an isolated rat heart model of ischemia and reperfusion injury. Danshensu (60 mg/kg per day) reduces infarct size and improves left ventricular function in a rat model of myocardial infarction. It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model. Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.

Chemical Properties

White to light brown powder

Uses

Sodium Danshensu is exhibits protective effects on the excitotoxicity of monosodium glutamate in the late stage of pregnancy on developing mouse fetal brain.

Upstream product

• 19764-32-0 Ac-D-Tyrosine 
• 60470-85-1 (Z)-3-(4-Acetoxy-phenyl)-2-acetylamino-acrylic acid methyl ester 
• 38243-39-9 α-acetylamino-4-hydroxy-cinnamic acid 
• 556-02-5 tyrosine 

Downstream Products

• 203798-74-7 (R)-methyl 3-(3,4-bis(benzyloxy)phenyl)-2-hydroxypropanoate 
• 1388829-35-3 C₆₁H₅₀O₁₀ 
• 1388829-33-1 (R,E)-1-methoxycarbonyl-2-[3,4-bis(benzyloxy)phenyl]ethyl-3-[7-(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]-1-benzofuran-4-yl]acrylate 

Relevant articles and documents

D-tyrosine a method for asymmetric synthesis of

A provided asymmetric syntheses method for D-tyrosine comprises the following steps: performing a condensation reaction on p-hydroxybenzaldehyde and acetylglycine, then performing hydrolysis or alcoholysis to obtain a dehyddroamino acid or ester; and then utilizing rhodium to perform catalytic asymmetric hydrogenation, and performing hydrolysis to obtain a key intermediate D-tyrosine. According to the method, the whole process has no complex separation steps, the preparation technology is simple, a chromatography column is not needed, the reaction steps can be further reduced by utilizing rhodium catalysis asymmetric hydrogenation technology, the production cost is reduced, and the method is extremely suitable for industrialized batch production.