679401-23-1Relevant academic research and scientific papers
Studies Towards the Large Scale Chemical Synthesis of the Precursors of Ribonucleosides-3′,4′,5′,5″-2H4 and -2′,3′,4′,5′,5″-2H5
Foeldesi, Andras,Chattopadhyaya, Jyoti
, p. 2093 - 2104 (2007/10/03)
A summary delineating the large scale synthetic studies to prepare labeled precursors of ribonucleosides-3′,4′,5′,5″- 2H4 and -2′,3′,4′,5′,5″ -2H5 from D-glucose is presented. The recycling of deuterium-labeled
Systematic synthesis of specifically 13C/2H-labeled nucleosides from [ul-13C6]-D-glucose
Ono, Akira Mei,Shiina, Toko,Ono, Akira,Kainosho, Masatsune
, p. 2793 - 2796 (2007/10/03)
A systematic approach, which combines previously reported reactions with appropriate modifications, was established for preparing a variety of selectively deuterated nucleosides from glucose. We have developed a systematic method of synthesizing specifically deuterated nucleosides from glucose. Selectively 13C/2H-doubly labeled nucleosides, such as [1',2',3',4',5'-13C5;3',5'-2H2]- and [1',2',3',4',5'-13C5;4',5'- H2]-adenosines, have been synthesized starting from [ul-13C6]-D-glucose. These labeled nucleosides are very useful for precise conformational analyses of nucleic acids in solution by heteronuclear multidimensional NMR spectroscopy.
