679437-24-2

Upstream product

• 679437-17-3 (2S,3R)-3-((S)-4-Benzyl-2-thioxo-oxazolidine-3-carbonyl)-2-hydroxy-6-phenyl-2-trifluoromethyl-hexanoic acid ethyl ester 
• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 96136-31-1 (S)-2-amino-3-(4-methoxyphenyl)-N-methylpropionamide 
• 679437-21-9 (2S,3R)-2-Hydroxy-3-(3-phenyl-propyl)-2-trifluoromethyl-succinic acid 1-ethyl ester 

Downstream Products

• 679437-30-0 N¹-benzyloxy-2-hydroxy-N⁴-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethyl]-3-(3-phenyl-propyl)-2-trifluoromethyl-succinamide 
• 679437-27-5 (2S,3R)-2-Hydroxy-3-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-phenyl-2-trifluoromethyl-hexanoic acid 

Relevant academic research and scientific papers

Stereochemically pure α-trifluoromethyl-malic hydroxamates: synthesis and evaluation as inhibitors of matrix metalloproteinases

The synthesis of trifluoromethyl (Tfm) analogs of known nanomolar matrix metalloproteinases (MMPs) inhibitors has been performed. The synthetic protocol is based on a moderately stereoselective aldol reaction of trifluoropyruvate with an N-acyl-oxazolidin

Synthesis and evaluation of stereopure α-trifluoromethyl-malic hydroxamates as inhibitors of matrix metalloproteinases

The total synthesis of trifluoromethyl (Tfm) analogs of known nanomolar matrix metalloproteinases (MMPs) inhibitors has been performed. The synthetic protocol is based on a moderately stereoselective aldol reaction of trifluoropyruvate with an N-acyl-oxaz