67947-51-7

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 6332-83-8 2-(4-chlorophenyl)-1-phenylethanone 
• 5365-44-6 thiophene-2-carbothioic acid S-methyl ester 
• 1281445-02-0 1-(4-chlorophenyl)-2-decanone 
• 188290-36-0 thiophene 
• 25026-34-0 4-chlorophenacetyl chloride 

Downstream Products

• 104941-08-4 2-(4-Chloro-phenyl)-1-thiophen-2-yl-propenone 
• 80161-85-9 N-ethyl-1-(2-thienyl)-2-(4-chlorophenyl)ethylamine hydrochloride 
• 80154-70-7 1-(2-thienyl)-2-(4-chlorophenyl)ethylamine hydrochloride 
• 188848-35-3 2-(4-Chloro-phenyl)-1-thiophen-2-yl-ethanol 
• 107659-22-3 2-(4-Chloro-phenyl)-2-hydroxy-3-imidazol-1-yl-1-thiophen-2-yl-propan-1-one 
• 80154-72-9 [2-(4-Chloro-phenyl)-1-thiophen-2-yl-ethyl]-diethyl-amine; hydrochloride 
• 80154-71-8 [2-(4-Chloro-phenyl)-1-thiophen-2-yl-ethyl]-isopropyl-amine; hydrochloride 
• 67947-52-8 2-bromo-2-(4-chlorophenyl)-1-(2-thienyl)ethanone 

Relevant academic research and scientific papers

Rhodium-catalyzed acyl-transfer reaction between benzyl ketones and thioesters: Synthesis of unsymmetric ketones by ketone CO-C bond cleavage and intermolecular rearrangement

In the presence of catalytic amounts of RhH(CO)(PPh3) 3 and 1,2-bis(diphenylphosphino)benzene (dppBz), acyl groups were transferred between benzyl ketones and thioesters/aryl esters. The rhodium complex catalyzed the cleavage of keto

Antifungal estrogen-like imidazoles. Synthesis and antifungal activities of thienyl and 1H-pyrrolyl derivatives of 1-aryl-2-(1H-imidazol-1-yl)ethane

Reaction of arylacetyl chlorides on thiophene or pyrrole derivatives furnished 2-aryl-1-(2-thienyl)- or 2-aryl-1-(1H-pyrrol-2-yl)-1-ethanones. Reduction of ketones to the corresponding carbinols and reaction of the latter compounds with 1,1'-sulfonyldiimidazole or 1,1'-carbonyldiimidazole gave 2-thienyl- and 1H-pyrrol-2-yl-1-aryl-2-(1H-imidazol-1-yl)ethanes, respectively. The new compounds were tested in vitro against a variety of pathogenic fungi in comparison with miconazole and bifonazole. Some a 5-chloro-2-thienyl derivatives were endowed with good antifungal activity, particularly against Candida albicans and Cryptococcus neoformans.

Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones

To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '

1-(2-Thienyl)-2-phenylethylamines as potential non-stimulant anorectics

A series of 1-(2-thienyl)-2-phenylethylamines was synthesized and tested for anorectic and motor activity effects in rats. Phenyl ring substituents included Cl, Br, F, CF3, CH3, OCH3, and NO2; amino group substi

Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones

Antiinflammatory 4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones, such as, 4-(4-fluorophenyl)-2-(1,1,2,2-tetrafluoroethylsulfonyl)-5-(2-thienyl)-1H-imidazole, useful for treating arthritis and related diseases.