67948-47-4

Upstream product

• 63525-16-6 1-phenyl-3-chloro-2-buten-1-one 
• 93-91-4 1-phenylbutan-1,3-dione 

Downstream Products

• 3969-09-3 2-methyl-5-phenyl-1,3-oxazole 
• 1008-75-9 3-methyl-5-phenylisoxazole 
• 1349782-60-0 C₁₀H₉NO 
• 51315-03-8 (3-methyl-2H-azirin-2-yl)(phenyl)- methanone 
• 56464-02-9 N-(4-benzoyl-5-methyl-2-phenyl-1H-pyrrol-3-yl)-4-methylbenzenesulfonamide 
• 1132922-57-6 URB₄₄₇ 

Relevant academic research and scientific papers

RhII-catalyzed [3+2] cycloaddition of 2 H-azirines with N-sulfonyl-1,2,3-triazoles

RhII-catalyzed intermolecular [3+2] cycloaddition of 2 H-azirines with N-sulfonyl-1,2,3-triazoles is disclosed, in which a series of fully functionalized pyrroles is produced via rhodium azavinyl carbene intermediates. A distinct feature of this reaction is that the azavinyl carbene serves as a [2 C] equivalent, instead of as [1 C] or aza-[3 C] synthons, which have been reported previously in cyclopropanations and [3 + n] cycloadditions. Moreover, this methodology has also been successfully applied in the total synthesis of URB447 as well as the formal synthesis of Atorvastatin (Lipitor).