67979-25-3 Usage
Description
Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities. It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 13.6 μM). Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner. It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen. Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS). It is larvicidal against A. gambiae mosquitoes (LD50 = 10 ppm).
Uses
A compound found in herbal remedies, believed to have an effect on blood platelet aggregation and lower blood lipid count
Definition
ChEBI: A trihydroxyanthraquinone that is 1,3,7-trihydroxy-9,10-anthraquinone which is by methoxy groups at positions 2 and 8, and by a methyl group at position 6.
Check Digit Verification of cas no
The CAS Registry Mumber 67979-25-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,9,7 and 9 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 67979-25:
(7*6)+(6*7)+(5*9)+(4*7)+(3*9)+(2*2)+(1*5)=193
193 % 10 = 3
So 67979-25-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H14O7/c1-6-4-7-11(17(24-3)12(6)19)14(21)10-8(13(7)20)5-9(18)16(23-2)15(10)22/h4-5,18-19,22H,1-3H3
67979-25-3Relevant articles and documents
SYNTHESIS OF SPECIFICALLY O-ALKYLATED ANTHRAQUINONES BY CYCLOADDITION
Cameron, Donald W.,Feutrill, Geoffrey I.,Gamble, Glenn B.,Stavrakis, John
, p. 4999 - 5002 (2007/10/02)
Cycloadducts from naphthoquinonoid dienophiles and 1-methoxy-1-trimethylsilyloxy butadienes undergo controlled aromatisation to form chiefly α-hydroxy- or α-methoxy-anthraquinones; this has led to synthesis of several natural O-methyl polyoxyanthraquinones.
