679794-85-5Relevant academic research and scientific papers
Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa
Lazarova, Tsvetelina I.,Jin, Lei,Rynkiewicz, Michael,Gorga, Joan C.,Bibbins, Frank,Meyers, Harold V.,Babine, Robert,Strickler, James
, p. 5022 - 5027 (2006)
A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor complexes led to the design and synthesis of second generation compounds showing single digit m
