6798-33-0

Usage

Uses

Used in Pharmaceutical Industry:
Benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate is used as an antirheumatic agent for the treatment of gout and hyperuricemia. It is effective in reducing the levels of uric acid in the body, providing relief from the symptoms associated with these conditions.
Used in Gout Management:
Benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate is used as a uricosuric agent to increase the excretion of uric acid in the urine, helping to prevent the formation of uric acid crystals and reduce the risk of gout attacks.
Used in Research:
Benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate is used as a subject of study for its potential anti-inflammatory and antioxidant properties, which could lead to the development of new treatments for various inflammatory and oxidative stress-related conditions.
Used in Drug Safety Monitoring:
Due to its association with rare but severe liver toxicity, benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate is used as a case study for monitoring drug safety and understanding the potential adverse effects of medications, ensuring that their benefits outweigh the risks for patients.

InChI:InChI=1/C10H10F3NO3/c11-10(12,13)8(15)14-9(16)17-6-7-4-2-1-3-5-7/h1-5,8,15H,6H2,(H,14,16)

Upstream product

• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 621-84-1 O-benzyl carbamate 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 1464-86-4 2,2,2-Trifluor-1-ethansulfonyl-N-benzyloxycarbonyl-ethylamin 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 

Downstream Products

• 6776-48-3 benzyl N-(1-chloro-2,2,2-trifluoroethyl)carbamate 
• 625093-77-8 diethyl {1-[(benzyloxycarbonyl)amino]-2,2,2-trifluoroethyl}phosphonate 
• 2310-89-6 phenyl hydrogen phosphonate 
• 6776-31-4 2,2,2-Trifluor-1-acetoxy-N-benzyloxycarbonyl-ethylamin 
• 625093-98-3 C₁₆H₂₄F₃N₂O₄P 
• 10124-01-3 N-Benzyloxycarbonyl-3,3,3-trifluor-DL-alanin-cyclohexylamid 
• 17049-78-4 trifluoro-acetic acid 1-benzyloxycarbonylamino-2,2,2-trifluoro-ethyl ester 
• 625093-88-1 (1-benzyloxycarbonylamino-2,2,2-trifluoro-ethyl)-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Preparation method of chiral trifluoromethyl amine derivatives

The invention discloses a preparation method of chiral trifluoromethyl amine derivatives. The structural formula of the chiral trifluoromethyl amine derivatives is shown in a formula I; the preparation method comprises the following steps: mixing carbonyl compounds and N, O-acetal with a chiral tertiary diamine organic small molecule catalyst and acid and then carrying out a reaction so as to obtain the chiral trifluoromethyl amine compounds. The chiral trifluoromethyl amine compounds are prepared by using the chiral tertiary diamine organic small molecule catalyst with a simple structure forcatalyzing without needing a solvent, and are synthesized in one step, so that the preparation method is simple and efficient. (The formula I is described in the description.).

A chiral α - amino acid derivative and its preparation method (by machine translation)

The invention discloses a chiral α - amino acid derivative and its preparation method. The invention α - chiral amino acid derivatives, its structural formula shown in formula I: Its preparation method, comprises the following steps: with the carbonyl compound to the N, O - acetal of the mixture with a chiral primary uncle diamine organic small molecule catalyst, strong and weak acid mixing, reaction, to obtain the chiral α - amino acid compounds; the carbonyl compound including aldehyde and/or ketone. The invention chiral α - amino acid ester compound having a simple structure of the chiral primary uncle diamine organic small molecule catalyst catalytic, solvent-free, one-step synthesis, simple, high-efficiency. (by machine translation)

Synthesis of α-trifluoromethyl-α-hydroxycarboxylate dervatives and their phosphorus-containing analogs with the use of fluorinated diazo compounds

Approach was developed underlain by the use of fluorinated diazocompounds to the synthesis of derivatives of α-trifluoromethyl-α- hydroxycarboxylic acids and their phosphorus-containing analogs, α-trifluoromethyl-α-hydroxyphosphonic acids. Methyl 2-diazo-3,3,3-trifluoropropionate and diethyl 1-diazo-2,2,2- trifluoroethylphosphonate under the action of catalytic quantities of dirhodium tetraacetate Rh2(OAc)4 easily inserted into the O-H bond leading to the formation of the corresponding products in high yields. Pleiades Publishing, Ltd., 2010.

1-Trifluoromethyl-1-diethoxyphosphoryl carbene: A new synthon for the preparation of CF3-containing α-hydroxy and α-amino phosphonic acid derivatives

The first synthesis of diethyl 1-diazo-2,2,2-trifluoroethylphosphonate has been developed starting from readily available compounds. The synthetic utility of this compound is demonstrated via its Rh-catalyzed insertion into O-H and N-H bonds to produce CF3-substituted α-hydroxy phosphonic and α-amino, phosphonic acid derivatives. Georg Thieme Verlag Stuttgart.

Expedient synthesis of perhaloaldehyde N-acyl hemiaminals

Various perhaloaldehyde N-acyl hemiaminals 1 are readily prepared in high yields by condensation of amides 7 with easily available perhaloaldehyde O-ethyl hemiacetals 8 or hydrates 9 in the presence of 5 A molecular sieves.