6798-35-2Relevant academic research and scientific papers
Synthesis of New 1Н-Pyrrolo[3,4-с]pyridine-1,3(2Н)-diones
Klyuchko,Chumachenko,Shablykin,Brovarets
, p. 348 - 356 (2021/04/26)
Abstract: A method for the synthesis of a series of new substituted 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones was proposed based on the Diels–Alder type reaction of 4-methoxy-1,3-oxazoles with maleimide derivatives.
In silico and in vitro studies of a number PILs as new antibacterials against MDR clinical isolate Acinetobacter baumannii
Trush, Maria M.,Kovalishyn, Vasyl,Hodyna, Diana,Golovchenko, Olexandr V.,Chumachenko, Svitlana,Tetko, Igor V.,Brovarets, Volodymyr S.,Metelytsia, Larysa
, p. 624 - 630 (2020/03/30)
QSAR analysis of a set of previously synthesized phosphonium ionic liquids (PILs) tested against Gram-negative multidrug-resistant clinical isolate Acinetobacter baumannii was done using the Online Chemical Modeling Environment (OCHEM). To overcome the pr
Synthesis of Novel 3-Aryl-5-dichloromethyl-Δ2-1,2,4-oxadiazolines
Guirado, Antonio,Sandoval, José A.,Alarcón, Enrique,Vera, María,Bautista, Delia,Gálvez, Jesús
, p. 1873 - 1878 (2019/05/15)
The first synthetic approach to hitherto unknown 3-aryl-5-dichloromethyl-Δ2-1,2,4-oxadiazolines, of synthetic and biological interest, has been developed involving high-yield reactions between N-(2,2-dichlorovinyl)benzimidoyl chlorides and hydr
New 1,3-oxazolylphosphonium salts as potential biocides: QSAR study, synthesis, antibacterial activity and toxicity evaluation
Trush, Maria M.,Kovalishyn, Vasyl,Ocheretniuk, Alla D.,Kalashnikova, Larisa E.,Prokopenko, Volodymyr M.,Holovchenko, Oleksandr V.,Kobzar, Oleksandr L.,Brovarets, Volodymyr S.,Metelytsia, Larisa O.
, p. 1259 - 1267 (2018/11/01)
Background: Due to the increase of multidrug-resistant microorganisms, the search for biologically active molecules does not stop. In the present study, we developed the effective QSAR model which allows a quick search of new potential Staphylococcus aure
Novel 2H-1,3-benzoxazine ring formation by intramolecular heterocyclization of N-(α-aryloxyalkyl)imidoyl chlorides
Onys'ko, Petro P.,Zamulko, Kateryna A.,Kyselyova, Olena I.,Syzonenko, Yaroslav A.
, p. 421 - 428 (2017/12/18)
A convenient synthetic approach to derivatives of 2-trichloromethyl and 2-dichlorometylene-2H-1,3-benzoxazines, based on intramolecular heterocyclization of readily accessible N-(α-aryloxytrichloroethyl)imidoyl chlorides, was developed. Base induced dehyd
A new, high-yield synthesis of 3-aryl-1,2,4-triazoles
Guirado, Antonio,López-Caracena, Libertad,López-Sánchez, José I.,Sandoval, José,Vera, María,Bautista, Delia,Gálvez, Jesús
, p. 8055 - 8060 (2016/11/19)
A convenient new synthetic approach to 3-aryl-1,2,4-triazoles has been developed. Chloralamides were obtained by high yield reactions between benzamides and chloral hydrate. These reacted with a phosphorus pentachloride/phosphorus oxychloride mixture unde
Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative
Long, Kai,Boyce, Michael,Lin, He,Yuan, Junying,Ma, Dawei
, p. 3849 - 3852 (2007/10/03)
The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification.
Potassium channel openers
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, (2008/06/13)
Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Potassium channel openers
-
, (2008/06/13)
Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Electrochemical generation of N-(2,2-dichlorovinyl)amides
Guirado, Antonio,Andreu, Raquel,Cerezo, Alfredo,Gálvez, Jesús
, p. 4925 - 4931 (2007/10/03)
A convenient method for the synthesis of N-(2,2-dichlorovinyl)amides has been established. Treatment of chloralamides with phosphorus pentachloride provides N-(1,2,2,2-tetrachloroethyl)amides in high yields whose electrochemical reduction leads to the tit
