6316-07-0Relevant articles and documents
Synthesis of New 1Н-Pyrrolo[3,4-с]pyridine-1,3(2Н)-diones
Klyuchko,Chumachenko,Shablykin,Brovarets
, p. 348 - 356 (2021/04/26)
Abstract: A method for the synthesis of a series of new substituted 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones was proposed based on the Diels–Alder type reaction of 4-methoxy-1,3-oxazoles with maleimide derivatives.
Novel 2H-1,3-benzoxazine ring formation by intramolecular heterocyclization of N-(α-aryloxyalkyl)imidoyl chlorides
Onys'ko, Petro P.,Zamulko, Kateryna A.,Kyselyova, Olena I.,Syzonenko, Yaroslav A.
, p. 421 - 428 (2017/12/18)
A convenient synthetic approach to derivatives of 2-trichloromethyl and 2-dichlorometylene-2H-1,3-benzoxazines, based on intramolecular heterocyclization of readily accessible N-(α-aryloxytrichloroethyl)imidoyl chlorides, was developed. Base induced dehyd
A facile synthesis of 1,3-thiazole-4-sulfonyl chlorides
Demydchuk, Bogdan A.,Kondratyuk, Kostyantyn M.,Korniyenko, Andrey N.,Brovarets, Vladimir S.,Vasylyshyn, Roman Y.,Tolmachev, Andrey,Lukin, Oleg
experimental part, p. 2866 - 2875 (2012/07/16)
(Chemical Equation Presented) A four-step preparative-scale synthesis of eight 2-alkyl- and arylsubstituted thiazole-4-sulfonyl chlorides from chloralamides is reported. Good yields and easy availability of starting materials are valuable advantages of the procedure that gives access to formerly unattainable building blocks. Copyright Taylor & Francis Group, LLC.
Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative
Long, Kai,Boyce, Michael,Lin, He,Yuan, Junying,Ma, Dawei
, p. 3849 - 3852 (2007/10/03)
The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification.
Sml2-mediated facile syntheses of N(2,2-dichlorovinyl)amides from acetates of chloralamide
Li, Jian,Wang, Xiaoxia,Zhang, Yongmin
, p. 738 - 739 (2007/10/03)
Samarium diiodide-mediated elimination reaction provides a simple and general method to synthesise N-(2, 2-dichlorovinyl)amides 4 from acetates of chloralamides 3 in excellent yields. This novel reaction proceeds readily within a few minutes at room tempe
Potassium channel openers
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, (2008/06/13)
Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Potassium channel openers
-
, (2008/06/13)
Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Synthesis of α-(acylamino)polyhaloalkylphosphoryl compounds by the reaction of trivalent phosphorus chlorides with N-(α-hydroxypolyhaloalkyl)amides
Onys'ko
, p. 1763 - 1767 (2007/10/03)
N-(α-Hydroxypolyhaloalkyl)amides react with trivalent phosphorus chlorides to give α-(acylamino)polyhaloalkylphosphoryl compounds via phosphorotropic rearrangement of intermediate phosphites or phosphinites.
REACTION OF N,N-DICHLOROAMIDES WITH TRICHLOROETHYLENE
Mirskova, A. N.,Levkovskaya, G. G.,Gogoberidze, I. T.,Kalikhman, I. D.,Voronkov, M. G.
, p. 239 - 241 (2007/10/02)
The reaction of N,N-dichloroacetamide and N,N-dichlorobenzamide with trichloroethylene in an inert atmosphere leads to the formation of the products from the transformation of the corresponding acylimines of chloral, i.e. 2,2,2-trichloro-1,1-di(acetamido)benzamido ethanes, N-(2,2,2-trichloro-1-hydroxyethyl)acetamides and the corresponding benzamides, and pentachloroethane.In the reaction of N,N-dichlorobenzamide with trichloroethylene in the presence of atmospheric oxygen N-(dichloroacetyl)benzamide is obtained in additon to N-(2,2,2-trichloro-1-hydroxyethyl)benzamide and pentachloroethane.Its formation results from the parallel processes of oxidation of the trichloroethylene to dichloroacetyl chloride and reduction of the dichlorobenzamide to benzamide and their reaction.