67980-08-9Relevant academic research and scientific papers
Synthesis of a new polycyclic heterocyclic ring system. Part III. Benzo[b]imidazo[1,5-d][1,4]oxazepine-1,4(2H,5H)-diones
Stanisheva, Desislava V.,Gerova, Mariana S.,Petrov, Ognyan I.
, p. 23 - 27 (2017/03/01)
A series of novel tricyclic benzoxazepines with fused imidazolone ring was prepared in five steps starting from the corresponding benzoxazolones 1-3. The key to the reported synthetic approach is transformation of 3-(2-oxopropyl)-2(3H)-benzoxazolones 4-6 to 1-(2-hydroxyphenyl)-4-methyl-1,3-dihydro-2H-imidazol-2-ones 7-12, and their subsequent conversion to the phenoxyacetic acids 19-24, which were finally acylated in polyphosphoric acid to form the oxazepine ring.
