679809-48-4Relevant academic research and scientific papers
Tetrahydro-4-quinolinamines identified as novel P2Y1 receptor antagonists
Morales-Ramos, Angel I.,Mecom, John S.,Kiesow, Terry J.,Graybill, Todd L.,Brown, Gregory D.,Aiyar, Nambi V.,Davenport, Elizabeth A.,Kallal, Lorena A.,Knapp-Reed, Beth A.,Li, Peng,Londregan, Allyn T.,Morrow, Dwight M.,Senadhi, Shobha,Thalji, Reema K.,Zhao, Steve,Burns-Kurtis, Cynthia L.,Marino Jr., Joseph P.
scheme or table, p. 6222 - 6226 (2009/09/06)
High-throughput screening of the GSK compound collection against the P2Y1 receptor identified a novel series of tetrahydro-4-quinolinamine antagonists. Optimal substitution around the piperidine group was pivotal for ensuring activity. An exemplar analog from this series was shown to inhibit platelet aggregation.
