67984-95-6

Usage

Derivative of quinoline

Quinoline is the base structure from which 1-ETHYL-2-OXO-QUINOLINE-3-CARBOXYLIC ACID is derived This means that the compound is structurally similar to quinoline, with some modifications to its structure.

Contains a carboxylic acid group

The presence of a -COOH group in the molecule This functional group is responsible for the acidic properties of the compound.

Potential biological applications

1-Ethyl-2-oxo-quinoline-3-carboxylic acid has been studied for its possible uses in biology This suggests that the compound may have an impact on living organisms or biological processes.

Promising activity as an antibacterial agent

The compound has shown potential in fighting bacterial infections This means it could be used as a treatment for bacterial infections in the future.

Promising activity as an antifungal agent

The compound has also shown potential in fighting fungal infections This indicates that it may be effective against fungi and could be used in treating fungal infections.

Potential use in the synthesis of pharmaceutical drugs

1-Ethyl-2-oxo-quinoline-3-carboxylic acid has been investigated for its possible role in creating new medications This suggests that the compound could be a valuable building block in the development of new drugs.

Potential use in the synthesis of other organic compounds

The compound may also be useful in creating other organic molecules This means that it could have a wide range of applications in the field of organic chemistry.

Of interest to researchers and scientists

1-Ethyl-2-oxo-quinoline-3-carboxylic acid is being studied for its potential medicinal and synthetic utility This highlights the importance of the compound in the scientific community and its potential impact on various fields.

Upstream product

• 59997-14-7 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione 
• 552-89-6 2-nitro-benzaldehyde 
• 325958-16-5 1-ethyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 66095-55-4 10-ethyl-3-methyl-1,5-dihydro-5-deazaflavin 
• 85870-47-9 1,2-dihydro-2-oxo-3-quinolinecarboxylic acid,ethyl ester 
• 17422-56-9 diethyl 2-(2-nitrobenzylidene)malonate 

Relevant academic research and scientific papers

4-hydroxy-2-quinolones. 178*. irreversible chemical modification of chinoxicaine at the position 4 of the quinolone ring

While continuing our investigation in improving the pharmaceutical activities of the local anesthetic Chinoxicaine we have studied the irreversible replacement of its 4-OH group for bioisosteric fragments. For this purpose the synthesis of a series of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-(diethylamino)ethylamide hydrochlorides has been carried out. The experimental data of the local anesthetic properties of the compounds obtained are given and discussed.

Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as serotonin 5-HT4 receptor agonists

A series of N-azabicycloalkyl-1-alkyl-2-oxo-1,2-dihydro-3-quinolinecarboxamides were synthesized and tested for serotonin 5-HT4 receptor-stimulating effects in the regulation of electrically-evoked contraction in guinea pig muscle. Among them, N-azabicycloalkyl-1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxamide (8c, 9c, 10c, 11c, 12c) exhibited potent serotonin 5-HT4 receptor-stimulating activity. The most potent compound, N-(endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-isopropyl-2-oxo-1,2-dihydro-3 -quinolinecarboxamide (8c, ED50= 36.3 nM), was seven times as active as cisapride, while 8c had no affinity for 5-HT,1A, 5-HT1D, D2, muscarinic M2 or muscarinic M3 receptors even at 10 μM. Compound 8c stimulated digestive tract motility in conscious fed dogs (1.0 mg/kg p.o.).

Disproportionation in Hydrolysis of Pyrimidoquinoline-2(3H),4(10H)-diones (5-Deazaflavins)

Treatment of 5-deazaflavins with concentrated aqueous potassium hydroxide led to the exclusive formation of 1,5-dihydro-5-deazaflavins and 1,5-dihydro-5-deazaflavin-5-ones via intermolecular oxidation-reduction between initially formed 5-hydroxy-1,5-dihydro-5-deazaflavins and unchanged 5-deazaflavins; under dilute alkaline conditions the reverse oxidation-reduction between 1,5-dihydro-5-deazaflavins and 1,5-dihydro-5-deazaflavin-5-ones occurred to form the original 5-deazaflavins and 5-hydroxy-1,5-dihydro-5-deazaflavins, which were oxidized to 1,5-dihydro-5-deazaflavin-5-ones by air.When hydrolysis was carried out with dilute alkaline solution, the corresponding 2-oxoquinoline-3-carboxylic acids were obtained besides the disproportionation products 1,5-dihydro-5-deazaflavins and 1,5-dihydro-5-deazaflavin-5-ones.This disproportionation and hydrolytic scission at the 2-position complete with each other.Higher concentrations of hydroxide ion favoured the formation of the reduced 5-deazaflavins and 5-ketones by disproportionation and reduced the proportion of 2-quinolones formed by hydrolytic scission.