67986-36-1Relevant academic research and scientific papers
Method for synthesizing 2-carbonyl thienopyridine compound
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Paragraph 0030; 0031; 0032; 0033, (2019/01/08)
The invention discloses a method for synthesizing 2-carbonyl thienopyridine compound. According to the method provided by the invention, 2-halo-3-alkynol pyridine as shown in formula (I) and sulfur sources are mixed; and with the aid of a catalyst, after reacting in a solvent for a while, 2-carbonyl thienopyridine compound as shown in formula (II) is prepared after purification treatment. The sulfur sources are selected from one or more of elemental sulphur, ammonium sulfide, thiourea, sodium sulfide, and ethyl potassium xanthate, and the catalyst is selected from one of copper acetate, cuprous iodide, cuprous bromide, cuprous chloride, copper chloride, cupric acetylacetonate, palladium chloride, and copper trifluoromethanesulfonate. The technical scheme of the invention has the advantagesof less reaction steps, simple operation method, wide source of reaction substrate, low costs and easy availability of the catalyst, high product yield and the like, and the technical scheme is verysuitable for industrial mass production. The formulas are shown in the description.
2-Acetylthienopyridine Synthesis via Thiolation and Copper-Catalyzed Cyclization of o-Propynol Fluoropyridine Using Xanthate as a Thiol Surrogate
Li, Yibiao,Luo, Xianglin,Shao, Yan,Chen, Lu
, p. 8768 - 8774 (2018/07/25)
2-Acylthienopyridines and related heterocycles are readily prepared in moderate to good yields under mild conditions by a nucleophilic thiolation, copper-catalyzed cyclization, and an oxidation cascade process using potassium xanthate as the thiol source.
The Synthesis of Thienopyridine Derivatives
Molina, P.,Alajarin, M.,Perez de Vega, M. J.,Becher, J.
, p. 342 - 344 (2007/10/02)
Thienopyridine derivatives 3 are prepared either by the reaction of pyridine-2-thiones 1 with phenacyl bromides or by bromination of vinyl ketones 2.
