68007-29-4

Upstream product

• 628-20-6 4-Chlorobutyronitrile 
• 100-58-3 phenylmagnesium bromide 
• 5264-35-7 2-methoxy-1-pyrroline 
• 555-24-8 lithium phenolate 
• 69105-60-8 5-phenyl-3,4-dihydro-2H-pyrrole perchlorate 
• 71-43-2 benzene 

Relevant academic research and scientific papers

1-Substituted cyclopentylamines from nitriles and tetramethylenebismagnesium dibromide in the presence of Ti(OiPr)4

Various 1-substituted cyclopentylamines (25 examples, 1089 % yield) have been prepared according to a one-pot procedure by the addition of tetramethylenebismagnesium. di- bromide in the presence of Ti(OiPr)4 to aliphatic, aromatic and heteroaromatic nitriles, respectively.

Treatment of bacterial induced diseases using DNA methyl transferase inhibitors

Methods for treating and/or preventing disease conditions caused or induced or aggravated by microbes, especially bacteria, by inhibiting DNA methyltransferase activity, such as by administering to an animal a DNA methyltransferase inhibitor, are disclosed, along with methods of reducing or ablating virulence in bacteria by inhibiting DNA methyltransferase activity.

DNA Methyltransferase inhibitors

A compound of the formula or a pharmaceutically acceptable salt thereof,whereinR1, R2, and R3 are the same or different and are independently hydrogen, lower alkyl, aryl or substituted aryl, lower alkoxy, lower alkoxyalkyl, or cycloalkyl or cycloalkyl alkoxy, where each cycloalkyl group has from 3-7 members, where up to two of the cycloalkyl members are optionally hetero atoms selected from oxygen and nitrogen, and where any member of the alkyl, aryl or cycloalkyl group is optionally substituted with halogen, lower alkyl or lower alkoxy, aryl or substituted aryl, andwhereR3 can be ribose, deoxyribose or phosphorylated derivatives thereof,whereinR1, R2, and R3 are not all hydrogen andwhereinwhen R3 is ribose, deoxyribose or phosphorylated derivatives thereof, one of R1 or R2 is not hydrogen.

Arene-Iminium Salt Electron-Transfer Photochemistry. Mechanistically Interesting Photoaddition Processes

Studies of the electron-transfer photochemistry of arene-iminium salt systems have been explored.Fluorescence quenching investigations have demonstrated that a series of arenes including substituted toluenes and benzenes quench the fluorescence of a variety of 2-aryl-1-pyrrolinium perchlorates.Quenching rate constants in these cases correlate with the ΔGSET values as expected for quenching by reversible electron-transfer pathways.In addition, nonconjugated iminium salts quench the fluorescence of a host of arenes with kq values which parallel those predicted on the basis of electron-transfer free energy calculations.Photoaddition reactions of toluene, benzyltrimethylstannane, and 2-aryl-1-pyrrolinium salts have been explored.Likewise, electron-transfer-induced, excited-state reactions of toluene and benzyltrimethylsilane with 1,2-dimethyl-1-pyrrolinium perchlorate have been investigated.The results of these photoreactions have been interpreted in terms of steric, electrofugal group, and solvent effects upon the rates of competitive pathways available to initially formed radical cation pair intermediates.Finally, the photochemistry of benzyltrimethylstannane is described.