680183-40-8Relevant academic research and scientific papers
The tertiary sulfonamide as a latent directed-metalation group: Ni 0-catalyzed reductive cleavage and cross-coupling reactions of aryl sulfonamides with Grignard reagents
Milburn, Robert R.,Snieckus, Victor
, p. 888 - 891 (2004)
A mild method for the Ni0-catalyzed hydrodesulfamoylation (see scheme, B) of aryl sulfonamides (1→2) with iPr2Mg or iPrMgCl as β-hydride transfer sources can be linked with directed ortho metalation (A and C) to give meta-substituted aromatics 2. Cross-coupling process with alkyl and aryl Grignard reagents furnish disubstituted benzenes and bi- and teraryl compounds.
