680186-38-3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 680186-43-0 (Z)-4-(2-bromo-1-fluoroethenyl)-1-trityl-1H-imidazole 
• 86803-29-4 4-ethenyl-1-(triphenylmethyl)-1H-imidazole 
• 438206-59-8 (Z)-2-bromo-3-(1-trityl-1H-imidazol-4-yl)acrylic acid methyl ester 
• 680186-41-8 4-(1,2-dibromoethyl)-1-trityl-1H-imidazole 

Downstream Products

• 680186-47-4 (1-trityl-1H-imidazol-4-yl)-propynoic acid ethyl ester 
• 680186-45-2 (E)-2-bromo-3-fluoro-3-(1-trityl-1H-imidazol-4-yl)prop-2-en-1-ol 
• 438206-68-9 (Z)-3-fluoro-3-(1-trityl-1H-imidazol-4-yl)prop-2-en-1-ol 
• 680186-40-7 3-(1-trityl-1H-imidazol-4-yl)-prop-2-yn-1-ol 
• 438206-61-2 (E)-3-fluoro-3-(1-trityl-1H-imidazol-4-yl)prop-2-en-1-ol 
• 680186-43-0 (Z)-4-(2-bromo-1-fluoroethenyl)-1-trityl-1H-imidazole 

Relevant academic research and scientific papers

NOVEL TUBULIN POLYMERISATION INHIBITORS

The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds.

New approaches to side-chain fluorinated bioimidazoles: 4-alkynylimidazoles as substrates for fluorination

4-Alkynylimidazoles have been prepared and their behavior as substrates for "FBr" addition (NBS+Et3N·3HF) have been studied. Facile Markownikov addition to ethylnylimidazole 2 gave fluorobromoolefin 9a, a potential synthon for the 2-imidazolyl-

1H-4(5)-substituted imidazole derivatives

The present invention provides, in its principal aspect, compounds of the general formula: when A is -NHCO-, -N(CH3)-CO-, -NHCH2-, -N(CH3)-CH2-, -CH=CH-, -COCH2-, CH2CH2-, -CH(OH)CH2- or -C 3BOND C-; X can be H, CH3, NH2, NH(CH3),N(CH3)2, OH, OCH3, SH, R2