680199-28-4Relevant academic research and scientific papers
NITROANILINE-BASED ALKYLATING AGENTS AND THEIR USE AS PRODRUGS
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Page 13; 23-24, (2008/06/13)
Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as produgs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjuction with nit
Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy
Friedlos, Frank,Denny, William A.,Palmer, Brian D.,Springer, Caroline J.
, p. 1270 - 1275 (2007/10/03)
Twenty nitrogen mustard analogues derived from 5-(aziridin-l-yl)-2,4- dinitrobenzamide (CB 1954, 1) were evaluated as candidate prodrugs for gene- directed enzyme prodrug therapy (GDEPT) in Chinese hamster V79 cell lines engineered to express Escherichia
