6802-49-9Relevant academic research and scientific papers
Synthesis method of 2-aminopyrimidine antiplatelet compound
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Paragraph 0039-0042; 0065-0068, (2019/11/21)
The invention discloses a synthesis method of a 2-aminopyrimidine antiplatelet compound, and the synthesis method comprises the following steps: selecting o-hydroxybenzaldehyde A and 2-bromoacetophenone B containing different substituent groups as raw materials, taking nitrogen heterocyclic carbene as a reaction catalyst, synthesizing an intermediate 1,3-diketone compound C of a novel antiplateletdrug under an alkaline condition, then synthesizing a flavonoid compound D under an acidic condition by the 1,3-diketone compound C, and finally generating the end product 2-aminopyrimidine antiplatelet compound E by the flavonoid compound D and guanidine hydrochloride under an alkaline condition. The synthesis method simplifies the original synthesis method from four steps to three steps, greatly simplifies the original synthesis method, thereby effectively reducing the production cost and the price of medicines, and improving the possibility for industrial production.
Assessment of antiplatelet activity of 2-aminopyrimidines
Giridhar, Rajani,Tamboli, Riyaj S.,Ramajayam,Prajapati, Dhaval G.,Yadav
scheme or table, p. 428 - 432 (2012/07/03)
A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds.
A two step synthesis of BzR/GABAergic active flavones via a Wacker-related oxidation
Lorenz, Michael,Shahjahan Kabir,Cook, James M.
experimental part, p. 1095 - 1098 (2010/04/05)
A general route for the synthesis of biologically important flavones is reported via a two step sequence employing a catalytic Wacker-Cook oxidation4b as the key step.
A Facile Preparation of Flavones Using Nonaqueous Cation-Exchange Resin
Hoshino, Yukio,Takeno, Noboru
, p. 1919 - 1920 (2007/10/02)
Flavone was prepared from 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione by using nonaqueous cation exchange resin in a nearly quantitative yield.Of several reaction media, isopropyl alcohol gave the best result.Eight substituted flavones were also synthesized from the corresponding diketones in satisfactory yields.
Cyclodehydrogenation of 2'-Hydroxychalcones with DDQ: A Simple Route for Flavones and Aurones
Imafuku, Kimiaki,Honda, Masaaki,McOmie, J. F. W.
, p. 199 - 201 (2007/10/02)
The oxidation of 2'-hydroxychalcones with 2,3-dichloro-5,6-dicyano-p-benzoquinone provides a useful synthetic route for flavones and aurones.
Utilization of "2-Pyrrolidone Hydrotribromide" in the Synthesis of Flavones
Takeno, Noboru,Fukushima, Tohoru,Takeda, Shin-ichi,Kishimoto, Kazuyasu
, p. 1599 - 1600 (2007/10/02)
The reaction of flavanone with "2-pyrrolidone hydrotribromide" in tetrahydrofuran gave 3-bromoflavanone in a good yield.On the other hand, flavone was obtained in 97percent yield when this reaction was carried out in dimethyl sulfoxide at 80 deg C.Under the same conditions, most flavones were obtained from the corresponding flavanones in high purity and good yiels.
