108238-40-0

Basic information

• Product Name: 7,3'-DIHYDROXYFLAVONE
• Synonyms: 7,3'-DIHYDROXYFLAVONE;Daizein;3,7-Dihydroxy-2-phenyl-4H-chroMen-4-one
• CAS NO: 108238-40-0
• Molecular Formula: C₁₅H₁₀O₄
• Molecular Weight: 254.24
• Mol File: 108238-40-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7,3'-DIHYDROXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7,3'-DIHYDROXYFLAVONE(108238-40-0)
• EPA Substance Registry System: 7,3'-DIHYDROXYFLAVONE(108238-40-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 108238-40-0(Hazardous Substances Data)

Upstream product

• 108-46-3 recorcinol 
• 25015-92-3 2-chloro-1-(2,4-dihydroxyphenyl)ethanone 
• 100-83-4 meta-hydroxybenzaldehyde 
• 742079-19-2 2-(3-benzyloxy-phenyl)-7-methoxy-chromen-4-one 
• 32272-16-5 7-methoxy-2-(3-methoxyphenyl)chroman-4-one 
• 6802-49-9 7,3'-Dimethoxyflavone 
• 56147-45-6 3,2',4'-triacetoxy-chalcone 
• 320576-70-3 2-(3-hydroxy-phenyl)-7-methoxy-chromen-4-one 

Downstream Products

• 320576-70-3 2-(3-hydroxy-phenyl)-7-methoxy-chromen-4-one 
• 145370-50-9 7-hydroxy-3'-methoxyflavone 

Relevant articles and documents

Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities

A novel series of 7-aminoalkyl-substituted flavonoid derivatives 5a-5r were designed, synthesized and evaluated as potential cholinesterase inhibitors. The results showed that most of the synthesized compounds exhibited potent acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities at the micromolar range. Compound 2-(naphthalen-1-yl)-7-(8-(pyrrolidin-1-yl)octyloxy)-4H-chromen-4-one (5q) showed the best inhibitory activity (IC50, 0.64 μM for AChE and 0.42 μM for BChE) which were better than our previously reported compounds and the commercially available cholinergic agent Rivastigmine. The results from a Lineweaver-Burk plot indicated a mixed-type inhibition for compound 5q with AChE and BChE. Furthermore, molecular modeling study showed that 5q targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Besides, these compounds (5a-5r) did not affect PC12 and HepG2 cell viability at the concentration of 10 μM. Consequently, these flavonoid derivatives should be further investigated as multipotent agents for the treatment of Alzheimer's disease.