680203-01-4

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-(4-methylbenzoyl)-, 1,1-dimethylethyl ester, (2S)-
• CAS NO: 680203-01-4
• Molecular Formula: C17H23NO3
• Molecular Weight: 289.375
• Mol File: 680203-01-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-(4-methylbenzoyl)-, 1,1-dimethylethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-(4-methylbenzoyl)-, 1,1-dimethylethyl ester, (2S)-(680203-01-4)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-(4-methylbenzoyl)-, 1,1-dimethylethyl ester, (2S)-(680203-01-4)

Safety Data

• Hazardous Substances Data: 680203-01-4(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 147-85-3 L-proline 
• 115186-37-3 tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate 
• 4294-57-9 para-methylphenylmagnesium bromide 

Relevant articles and documents

Synthesis of optically active N-protected α-aminoketones and α-amino alcohols

A series of optically active N-protected α-aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the N-tert-butoxycarbonyl amino acids. Reduction of the α-aminoketones by sodium borohydride resulted in the corresponding 1,2-amino alcohols.

COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS

The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.