680203-01-4Relevant academic research and scientific papers
Synthesis of optically active N-protected α-aminoketones and α-amino alcohols
Zhou, Zheng Hong,Tang, Yi Long,Li, Kang Ying,Liu, Bing,Tang, Chu Chi
, p. 603 - 606 (2003)
A series of optically active N-protected α-aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the N-tert-butoxycarbonyl amino acids. Reduction of the α-aminoketones by sodium borohydride resulted in the corresponding 1,2-amino alcohols.
Formal Fluorinative Ring Opening of 2-Benzoylpyrrolidines Utilizing [1,2]-Phospha-Brook Rearrangement for Synthesis of 2-Aryl-3-fluoropiperidines
Kondoh, Azusa,Ojima, Rihaku,Terada, Masahiro
supporting information, p. 7894 - 7899 (2021/10/20)
A ring expansion of 2-benzoylpyrrolidines, which involves the formal fluorinative ring opening utilizing the [1,2]-phospha-Brook rearrangement under Br?nsted base catalysis and a subsequent intramolecular reductive amination, was developed. The operationally simple three-step protocol provides an efficient access to 2-aryl-3-fluoropiperidines. The methodology was further applied to the syntheses of azepanes and tetrahydroquinolines.
COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS
-
Paragraph 001273; 001274; 001277; 001278, (2019/01/10)
The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.
CYCLIC AMINE COMPOUNDS
-
Page/Page column 49; 53, (2011/10/19)
Problems to be solved are to provide novel low-molecular compounds which exhibit calcium receptor antagonist activity, and which are highly safe and orally administrable. As a means for solving the problems, compounds having the Formula (I) or pharmaceuti
