680231-54-3

Upstream product

• 680231-49-6 (2R,3S)-3-amino-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one 
• 34619-03-9 tert-butyldicarbonate 
• 680231-48-5 (2R,3S)-3-azido-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one 
• 680231-47-4 (2R,3R)-3-hydroxy-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one 
• 893421-91-5 (6R,7S)-7-amino-6-phenyl-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 680231-66-7 tert-butyl [(2R,3S)-5-(cyclopropylmethyl)-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]carbamate 
• 680231-55-4 tert-butyl [(2R,3S)-4-oxo-2-phenyl-5-prop-2-yn-1-yl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl] carbamate 
• 680228-57-3 N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(2R,3S)-5-isopropyl-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-L-alaninamide 
• 680228-60-8 N₁-[(2R,3S)-5-(cyclopropylmethyl)-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-N₂-[(3,5-difluorophenyl)acetyl]-L-alaninamide 
• 680228-55-1 N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(2R,3S)-4-oxo-2-phenyl-5-prop-2-yn-1-yl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-L-alaninamide 
• 680231-63-4 (2R,3S)-3-amino-5-isopropyl-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one 
• 680231-56-5 (2R,3S)-3-amino-2-phenyl-5-prop-2-yn-1-yl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one 
• 680231-67-8 (2R,3S)-3-amino-5-(cyclopropylmethyl)-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one 
• 680231-64-5 ((6R,7S)-7-tert-butoxycarbonylamino-8-oxo-6-phenyl-7,8-dihydro-6H-5-oxa-9-aza-benzocyclohepten-9-yl)-acetic acid methyl ester 
• 680231-62-3 tert-butyl [(2R,3S)-5-isopropyl-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]carbamate 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

The invention provides a new method for treating disorders associated with activation of the Notch signal transduction pathway comprising administering an effective amount of a compound of Formula (I), in free form or in a pharmaceutically acceptable salt

NOVEL MOLECULAR PROBES

The present invention relates to novel molecular probes having the formula (I) (I) useful for the characterization, detection, localization and isolation of the γ-secretase enzyme.

NOVEL LACTAMS AND USES THEREOF

Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ? protein production and neurological disorders such as Alzheimer's disease.. These compounds inhibit γ secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.