68027-69-0Relevant academic research and scientific papers
NiCl2/CrCl2-mediated coupling reaction of ketones with alkenyl(or alkynyl, aryl) halides accomplished in the presence of a bipyridyl-type ligand
Chen, Chinpiao
, p. 1311 - 1312 (1998)
In this work, alkenyl halides (or triflates) and alkynyl (or aryl) halides are readily coupled with ketones in tetrahydrofuran in the presence of ligand 1, NiCl2 and CrCl2 at room temperature subsequently yielding the corresponding allylic alcohols, propargylic alcohols and benzylic alcohols.
Kinetic Resolution of Tertiary Propargylic Alcohols by Enantioselective Cu?H-Catalyzed Si?O Coupling
Seliger, Jan,Dong, Xichang,Oestreich, Martin
, p. 1970 - 1974 (2019/01/29)
A broad range of tertiary propargylic alcohols were kinetically resolved by catalyst-controlled enantioselective silylation. This non-enzymatic kinetic resolution is catalyzed by a Cu?H species and makes use of the commercially available precatalyst MesCu/(R,R)-Ph-BPE and a simple hydrosilane as the resolving reagent. Both alkyl,aryl- as well as dialkyl-substituted propargylic alcohols participate, and especially high selectivity factors are achieved when the alkyne terminus carries a TIPS group, which also enables facile post-functionalization in this position (s up to 207).
