68030-67-1Relevant academic research and scientific papers
OLIGONUCLEOTIDES AND NUCLEOTIDOPEPTIDES. XLII. EFFICACY OF THE INTRAMOLECULAR INFLUENCE OF THE CARBOXY GROUPS OF AMINO ACIDS IN NUCLEOTIDYL-(P-->N)-AMINO ACIDS (PEPTIDES) AS A FUNCTION OF THEIR POSITIONS
Yuodka, B. A.,Lioranchaite, L. E.,Baltenas, V. R.
, p. 703 - 708 (2007/10/02)
It has been established that remote carboxy groups in nucleotidyl-(5'-->N)-β-alanine and -alanylalanine do not affect the mechanism of the cleavage of the phosphoramide center.The situation is different in the case of nucleotidyl-(5'-->Nε)-lysine.It has been shown that in the 3'-phenylalanine derivative of dTMP, the influence of the α-carboxy group of the amino acid is only half as great as in the 5'-analog.The α-carboxy groups of the amino acids in oligonucleotidyl-(Pin-->N)-amino acids also weaken the mechanism of the cleavage of the phosphoramide centers.
