68031-94-7

Basic information

• Product Name: 2,6-bis (2-phenylethyl) pyridine
• Synonyms: 2,6-bis (2-phenylethyl) pyridine
• CAS NO: 68031-94-7
• Molecular Weight: 287.404
• Mol File: 68031-94-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,6-bis (2-phenylethyl) pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-bis (2-phenylethyl) pyridine(68031-94-7)
• EPA Substance Registry System: 2,6-bis (2-phenylethyl) pyridine(68031-94-7)

Safety Data

• Hazardous Substances Data: 68031-94-7(Hazardous Substances Data)

Upstream product

• 125311-40-2 2,6-distyrylpyridine 
• 10129-71-2 2,6-dibenzylidene-pyridine 
• 108-48-5 2,6-dimethylpyridine 
• 100-44-7 benzyl chloride 
• 536-74-3 phenylacetylene 
• 83965-72-4 2,6-bis(2-phenylethynyl)pyridine 
• 626-05-1 2,6-Dibromopyridine 
• 100-52-7 benzaldehyde 
• 79560-56-8 6-methyl-2-phenethyl-3,4-dihydropyridine 

Downstream Products

• 1428798-33-7 C₂₂H₂₄N⁽¹⁺⁾*CF₃O₃S^(1-) 
• 818377-18-3 Norlobelane 

Relevant articles and documents

Strategies to reduce hERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide

Drug-induced blockade of the human ether-a-go-go-related gene K+ channel (hERG) represents one of the major antitarget concerns in pharmaceutical industry. SAR studies of this ion channel have shed light on the structural requirements for hERG

PYRIDINES. PARTIE IX - PLURIBENZYLATION DE LA S-COLLIDINE ET DE LA LUTIDINE-2,6

A literature survey of the polymetalation of 2,6-lutidine 2 shows different results about the site(s) of deprotonation and condensation with various electrophiles.This discrepancy prompts us to examine the polylithiation (PhLi 3 equivalents, Et2O) of s-collidine 1, 2,6-lutidine 2 and more briefly of 2,4-lutidine 3.Polylithiation takes place exclusively at the methyl groups of the same position vs the ring nitrogen : 2- and/or 6-methyl of 1.The previous regioselectivity observed in the case of the monometalation in Et2O is maintained.From 1 and 2, polylithiation gives picolyl anions which lead by reaction with PhCH2Cl, simultaneously to mono-, di-symmetrical, di-non-symmetrical α-derivatives, and tri- and tetra-symmetrical α,α'-compounds; but no product is formed from a benzylic β-anion.In the same way, the deprotonation of 2-methyl-6-(2-phenylethyl) pyridine 17 leads to 2,6-bis (2-phenylethyl) pyridine 19 and 2-methyl-6-dibenzylmethyl pyridine 18, to the exclusion of the β-compound 2-methyl-6-(2,3-diphenylpropyl) pyridine 21.The latter compound is formed in low yield, besides 19 and 18, in the conditions of the Tchitchibabine reaction (NaNH2, toluene).The structure of the benzylated compounds was established mainly from the 1H-nmr data.No product was isolated which would result from the nucleophilic attack of the generated carbanions at the pyridine carbons.