68055-18-5Relevant academic research and scientific papers
Primary amines in the Willgerodt-Kindler reaction: an efficient conversion of aromatic aldehydes to thioamides
Kanyonyo, Martial R.,Gozzo, Andrea,Lambert, Didier M.,Lesieur, Daniel,Poupaert, Jacques H.
, p. 39 - 46 (2007/10/03)
This study reports the behaviour of aromatic aldehydes and aliphatic or alicyclic primary amines in the Willgerodt-Kindler reaction.Three different model substrates (benzaldehyde, 4-dimethylaminobenzaldehyde and 6-formyl-2(3H)benzoxazolinone) were investigated and a study of the solvent effect was carried out.When DMF was used as solvent, clean reactions and good yields were always obtained, which emphasizes the value of the Willgerodt-Kindler reaction in the functionalizing of aromatic aldehydes to thioamides.
