680986-68-9Relevant academic research and scientific papers
A Novel Class of P-O Monophosphite Ligands Derived from D-Mannitol: Broad Applications in High Enantioselective Rh-Catalyzed Hydrogenations
Huang, Hanmin,Zheng, Zhuo,Luo, Huili,Bai, Changmin,Hu, Xinquan,Chen, Huilin
, p. 2355 - 2361 (2007/10/03)
We report on a new class of P-O monophosphite ligands (designated 3a-k) with a double six-membered-ring backbone onto which are attached additional groups and on applications of their Rh complexes in the hydrogenation of enamides, α-dehydroamino acid esters, dimethyl itaconate, and β-(acylamino)acrylates. Our results demonstrate that the Rh complexes with ligands 3a-k exhibit high enantioselectivity and reactivity in asymmetric hydrogenation reactions. An ee value of up to 98.0% was obtained for the hydrogenation of α-dehydroamino acid esters, and the ee values were all over 99% for the other three types of substrate, with a turnover number of up to 5000.
