28224-73-9

Basic information

• Product Name: 1,3:4,6-DI-O-BENZYLIDENE-D-MANNITOL
• Synonyms: 1,3,4,6-DI-O-BENZYLIDENE-D-MANNITOL;1,3:4,6-DI-O-BENZYLIDENE-D-MANNITOL;1,3:4,6-bis-O-(phenylMethylene)-D-Mannitol;(4R,4'R,5R,5'R)-2,2'-Diphenyl-[4,4'-bi(1,3-dioxane)]-5,5'-diol
• CAS NO: 28224-73-9
• Molecular Formula: C₂₀H₂₂O₆
• Molecular Weight: 358.39
• Product Categories: 13C & 2H Sugars;Carbohydrates & Derivatives;Carbohydrate Synthesis;Monosaccharides;Specialty Synthesis;Aromatics;Heterocycles
• Mol File: 28224-73-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 192-195 °C
• Boiling Point: 595.4 °C at 760 mmHg
• Flash Point: 313.9 °C
• Appearance: /
• Density: 1.312 g/cm³
• Vapor Pressure: 5.05E-15mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: 2-8°C
• Solubility: Acetone (Slightly), Methanol ()Slightly
• PKA: 12.96±0.60(Predicted)
• BRN: 1627753
• CAS DataBase Reference: 1,3:4,6-DI-O-BENZYLIDENE-D-MANNITOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3:4,6-DI-O-BENZYLIDENE-D-MANNITOL(28224-73-9)
• EPA Substance Registry System: 1,3:4,6-DI-O-BENZYLIDENE-D-MANNITOL(28224-73-9)

Safety Data

• WGK Germany: 3
• F: 21
• Hazardous Substances Data: 28224-73-9(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

Uses

1,3:4,6-Di-O-benzylidene-D-mannitol (cas# 28224-73-9) is a compound useful in organic synthesis.

Purification Methods

1,3,4,6-Di-O-benzylidene-D-mannitol recrystallises from Et2O in long fine needles with at 256nm ( 435) in 95% EtOH, RF 0.21 (1:1 CCl4/EtOAc) on TLC Silica Gel G. [Sinclair Carbohydr Res 12 150 1970, ORD, CD, NMR, IR, MS: Brecknell et al. Aust J Chem 29 1749 1976, Beilstein 19/11 V 640.]

InChI:InChI=1/C20H22O6/c21-15-11-23-19(13-7-3-1-4-8-13)25-17(15)18-16(22)12-24-20(26-18)14-9-5-2-6-10-14/h1-10,15-22H,11-12H2/t15-,16-,17-,18?,19?,20?/m0/s1

Upstream product

• 608-66-2 D-galactitol 
• 100-52-7 benzaldehyde 
• 69-65-8 mannitol 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 5334-18-9 D-O²,O⁵-diacetyl-O¹,O³;O⁴,O⁶-((R,S)-dibenzylidene)-galactitol 
• 5349-05-3 D-O²,O⁵-dibenzoyl-O¹,O³;O⁴,O⁶-((R,S)-dibenzylidene)-galactitol 
• 99096-86-3 D-O²,O⁵-dibenzyl-O¹,O³;O⁴,O⁶-((R,S)-dibenzylidene)-galactitol 
• 28224-74-0 1,3:4,6-di-O-benzylidene-2,5-di-O-methanesulfonyl-D-mannitol 
• 23393-22-8 1,3:4,6-di-O-benzylidene-2,5-O-methylene-D-mannitol 
• 111248-46-5 N-amino-1,3:4,6-di-O-benzylidene-2,5-dideoxy-2,5-imino-L-iditol 
• 166372-23-2 1,3:4,6-di-O-benzylidene-2,5-di-O-allyl-D-mannitol 
• 17618-04-1 2,5-di-O-benzyl-D-mannitol 
• 99112-28-4 (2R,3S,4S,5R)-2,5-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-3,4-diol 
• 1144513-20-1 N-benzyl-1,3:4,6-di-O-benzylidene-2,5-dideoxy-2,5-imino-L-iditol 
• 847659-87-4 (4R,4'S,5R,5'R)-5'-(tert-butyldiphenylsilyloxy)-2,2'-diphenyl-4,4'-bi(1,3-dioxan)-5-ol 
• 36566-49-1 (4R,5R,6R,7R)-4,7-bis(hydroxymethyl)-1,3-dioxepane-5,6-diol 
• 1143516-28-2 4-O-benzyl-1,3-O-benzylidene-2,5-O-methylene-D-glycero-D-manno-heptitol 
• 1143516-32-8 4-O-benzyl-5,7-O-benzylidene-3,6-O-methylene-D-glycero-D-galacto-heptitol 

Relevant articles and documents

Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus

An extreme thermophile, Thermus thermophilus, has very unique glycolipids on the cell surface. The acidic immunostimulatory phosphoglycolipid of T. thermophilus was synthesized for the first time, with newly developed glycosylation methods using 3-nitropyridyl (3NPy) and 4,6-dimethoxy-1,3,5- triazin-2-yl (DMT) glycosides as glycosyl donors. The analogues of the phosphoglycolipid, which include a diastereomer possessing the opposite configuration at the diacyl glycerol moiety, were also synthesized. The biological activities of the synthesized compounds were elucidated with cytokine inductions (IL-6 and TNF-α). A synthetic phosphoglycolipid with a natural-type diacyl glycerol configuration showed apparent immunostimulatory activity, whereas its diastereomer did not. The present study revealed that the configuration at the diacyl glycerol moiety of the phosphoglycolipids is important for immunostimulation, suggesting the existence of the particular receptor/recognizing protein that can recognize the stereochemistry of the glycerol part.

New 3-O-lauroyl-2-O-benzyl-glycerol sulfonate

The hydroxy groups of D-mannitol were protected by the formation of acetals and benzylethers and then 2-O-benzyl-D-glyceraldehyde dimethylacetal was prepared after the deprotection and oxygenolysis of the protected D-mannitol. In the presence of DCC and D

New optically pure dimethylacetals of glyceraldehydes and their application for lipid and phospholipid synthesis

A convenient synthesis of new and enantiometrically pure 2-O-protected D-glyceraldehyde dimethylacetals as chiral C-3 building blocks for the synthesis of lipids and phospholipids is described.Benzyl- or allylethers are used as protecting groups in position 2 and 5 of D-mannitol.These intermediates are converted to 2-O-benzyl- or 2-O-alkyl-D-glyceraldehyde dimethylacetals by cleavage with periodic acid in methanol.The two dimethylacetals are useful for the synthesis of mixed chain phospholipids with natural configuration of ester-ester, ester-ether or ether-ether composition.Also, triglycerides with three different alkyl chains, ester of ether, can be prepared.As an example of the varsatility of the new intermediates, we describe the synthesis of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocho;ine, the so-called 'platelet activating factor' (PAF), via 1-O-hexadecyl-2-O-benzyl-sn-glycerol. Keywords: Synthetic phospholipids; PAF; Phospholipid analogues; Synthesis; Chiral pool; Glyceraldehyde; C-3 building blocks; Optical purity