68101-28-0Relevant academic research and scientific papers
Synthesis, Characterization, and Antioxidant Activity of a New Class of Amido linked Azolyl Thiophenes
Thatha, Sreenivasulu,Ummadi, Nagarjuna,Venkatapuram, Padmavathi,Adivireddy, Padmaja
, p. 1410 - 1418 (2018)
A new class of amido linked azolyl thiophenes was prepared from the synthetic intermediates azolyl amines and 5-chlorothiophene-2-carbonyl chloride adopting conventional and ultrasonication methodologies. It was observed that the reaction took place in shorter reaction times with higher yields under ultrasonication. The structures of the synthesized compounds were characterized by spectral parameters and also tested for antioxidant activity. Among all the tested compounds, methoxy substituted oxazolyl thiophene carboxamide (8c) displayed promising antioxidant activity. Besides, the electron donating groups on the phenyl ring enhanced the antioxidant activity when compared with the electron withdrawing groups.
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry
Annunziato, Giannamaria,Azzali, Elisa,Costantino, Gabriele,Girardini, Miriam,Mori, Giorgia,Pasca, Maria Rosalia,Pavone, Marialaura,Pieroni, Marco,Vacondio, Federica
supporting information, p. 1435 - 1441 (2020/08/19)
To obtain effective eradication of numerous infectious diseases such as tuberculosis, it is important to supply the medicinal chemistry arsenal with novel chemical agents. Isosterism and bioisosterism are widely known concepts in the field of early drug d
Comparative material study and synthesis of 4-(4-nitrophenyl)oxazol-2-amine via sonochemical and thermal method
Singh, Balvant S.,Lobo, Hyacintha R.,Pinjari, Dipak V.,Jarag, Krishna J.,Pandit, Aniruddha B.,Shankarling, Ganapati S.
, p. 633 - 639 (2013/02/22)
The present paper deals with the synthesis of aminooxazole derivatives via thermal and ultrasonic methods using deep eutectic solvent as medium. It was observed that ultrasound-assisted method gave 90% yield in just 8 min as against 3.5 h required to get
COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION
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Page/Page column 85, (2012/02/01)
Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.
A novel and efficient one pot synthesis of 2,4-disubstituted thiazoles and oxazoles using phenyltrimethylammoniumtribromide in ionic liquid
Muthyala, Manoj Kumar,Kumar, Anil
, p. 959 - 964 (2012/10/29)
A novel and efficient one-pot procedure has been described for synthesis of 2,4-disubstituted thiazoles and oxazoles from substituted ketones using phenyltrimethylammoniumtribromide as in situ brominating agent followed by reaction with thioamide/thiourea and amides/ureas, respectively in [bmim][BF4] ionicliquid. The advantages of the procedure include avoiding the handling of lacrymetric compounds, hazardous and toxic organic solvents along with good to excellent yield of the products.
