68104-29-0

Upstream product

• 100-52-7 benzaldehyde 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 107044-63-3 (2-Benzo[1,3]dioxol-5-yl-ethyl)-[1-phenyl-meth-(E)-ylidene]-amine 

Downstream Products

• 74421-92-4 benzyl-[2-(6-iodo-benzo[1,3]dioxol-5-yl)-ethyl]-amine 

Relevant academic research and scientific papers

TRNA SYNTHETASE INHIBITORS

Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis.

Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators

Berberine (BBR, 1) is a novel cholesterol-lowering agent that up-regulates low-density-lipoprotein receptor (LDLR) expression through a mechanism different from that of statins. Because of the unique mode of action and good safety record, BBR provoked our

Synthesis and antihyperglycemic evaluation of various protoberberine derivatives

Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of β-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.